NEW STRATEGIES FOR ENHANCING TISSUE INTEGRITY/REPAIR

该中心的主题是“增强组织的新策略” 完整和修复。两个互补的方法将是 以下：促进头面部组织的修复 发育或获得性缺陷；以及干预以防止 这些组织的破坏和退化。对于组织修复， 基本假设是正常的组织分化和成熟， 组织重塑和修复过程具有重要的 机械性特征。目标是发现正常的标记 发展和功能，并开发新的战略来刺激 再生修复。用于开发或获得性矿化 缺陷，其目的是增强组织形成。基本前提是 为了保持组织的完整性，很多颅面 发育和退行性疾病是可以预防的。因此， 诊断、风险评估、干预和教育宣传 可以使用策略来减少这些疾病的发生率和发病率。 精神错乱。规划拨款的目的是加强互动。 在基础、临床、社会和临床科学家中，以便为 研究、治疗方法、预防和推广战略 可能会出现；最终选择将包括在 最终建议；获得潜在患者的初步数据 用于风险评估、诊断、结果的人群 和教育研究的建议；并建立联系，以 促进与学术界、产业界和 北部地区的社区机构和资源 加利福尼亚。项目开发期将用于：开发 行政结构；选择最终提案的项目； 开发生物统计核心设施；扩大和发展与 区域研究机构和企业；扩大关系 与区域健康维护组织和健康保险公司合作； 制定临床医生科学家的教育和医疗保健计划 提供预防、干预和治疗战略；制定 一个世界范围的交流网站；并扩大筹款活动 能力以及制定分配COHRCD的流程 资金。

The theme of this center is "New strategies for enhancing tissue integrity and repair." Two complementary approaches will be followed: enhancing the repair of craniofacial tissues with developmental or acquired defects; and intervening to prevent the destruction and degeneration of these tissues. For tissue repair, the basic hypothesis is that normal tissue differentiation and maturation, and tissue remodeling and repair processes share important mechanistic features. The goal is to uncover markers for normal development and function, and develop novel strategies for stimulating regenerative repair. For developmental or acquired mineralization defects, the aims is to augment tissue formation. The basic premise for the maintenance of tissue integrity is that many craniofacial developmental and degenerative disorders are preventable. Thus diagnostic, risk-assessment, intervention and educational outreach strategies could be used to reduce the incidence and morbidity of these disorders. The aims of the planning grant are to enhance interactions among basic, clinical, social and clinical scientists so that new ideas for research, treatment approaches, prevention and outreach strategies may emerge; to make a final selection of projects to be included in the final proposal; to obtain preliminary data on potential patient populations to be used in the risk-assessment, diagnostic, outcomes and educational studies proposed; and to establish linkages that will foster productive interactions with the academic, industrial and community institutions and resources in the area of northern California. The project development period would be used to: develop the administrative structure; select the projects for the final proposal; develop a biostatistics core facility; expand and develop ties with regional research institutions and corporation; expand relationships with regional health maintenance organizations and health insurers; develop plans for education of clinician scientists and health care providers in prevention, intervention and treatment strategies; develop a world-wide web site for communication; and to expand fund-raising capabilities as well as develop a process for allocating COHRCD funds.