UK:Brazil Joint Centre Partnership in leishmaniasis

英国：巴西利什曼病联合中心合作伙伴关系

• 批准号: MR/S019472/1
• 负责人: Jeremy Mottram
• 金额: $ 153.67万
• 依托单位: University of York
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2019
• 资助国家: 英国
• 起止时间: 2019 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=MR%2FS019472%2F1
• 关键词: UK; Brazil; Joint; Centre; Partnership

Leishmaniasis is a neglected tropical disease of humans that primarily affects the poorest people in developing countries. There is currently no effective vaccine and treatment relies on chemotherapy with inadequate drugs as the first line approach for reducing the burden of disease. Visceral leishmaniasis (VL) is the most severe form of the disease and in Brazil it is caused by transmission of the protozoan parasite Leishmania infantum by sand flies; this leads to ~3,500 cases a year with ~10% deaths. Cutaneous leishmaniasis is also a significant public health concern, with Leishmania braziliensis being the most prevalent species. The UK:Brazil Joint Centre Partnership in leishmaniasis (JCPiL) will research the biology of the Leishmania parasite and its interaction with the mammalian host, primarily the human. Studies will be focused on understanding parasite genetic diversity in the context of variations in factors produced by Leishmania that evoke disease, mechanisms of immune evasion, diversity of host response and immunopathology. The Centre is built on a strong track record of current or recent joint projects with Brazil involving investigators from 3 UK Universities (York, Durham and Glasgow) and 3 Brazilian States (São Paulo, Rio de Janeiro and Piaui). Close collaborative working between Brazil and the UK investigators will facilitate the translation of fundamental research into new diagnostics and therapies. To this end the JCPiL will fund five inter-related projects and a workshop will take place to promote research at the interface of basic and clinical science, to extend existing collaborations between UK and Brazil and to develop new partnerships and interdisciplinary ways of working. Overall, we expect the outcome from this partnership to be a greatly improved understanding of how the parasite causes disease and how this knowledge can be exploited to develop novel therapies to treat leishmaniasis.

利什曼病是一种被忽视的人类热带疾病，主要影响发展中国家最贫困的人群。目前尚无有效的疫苗，治疗依靠药物不足的化疗作为减轻疾病负担的一线方法。内脏利什曼病 (VL) 是该病最严重的形式，在巴西，它是由白蛉传播原生动物寄生虫婴儿利什曼原虫引起的；这导致每年约 3,500 例病例，其中约 10% 死亡。皮肤利什曼病也是一个重大的公共卫生问题，其中巴西利什曼原虫是最流行的物种。英国：巴西利什曼病联合中心合作伙伴关系 (JCPiL) 将研究利什曼原虫的生物学及其与哺乳动物宿主（主要是人类）的相互作用。研究重点是了解利什曼原虫引起疾病的因素变化背景下的寄生虫遗传多样性、免疫逃避机制、宿主反应的多样性和免疫病理学。该中心建立在与巴西当前或最近的联合项目的良好记录之上，涉及来自 3 所英国大学（约克大学、达勒姆大学和格拉斯哥大学）和 3 个巴西州（圣保罗、里约热内卢和皮奥伊大学）的研究人员。巴西和英国研究人员之间的密切合作将促进基础研究转化为新的诊断和疗法。为此，JCPiL 将资助五个相互关联的项目，并将举办一个研讨会，以促进基础科学和临床科学交叉领域的研究，扩大英国和巴西之间的现有合作，并发展新的伙伴关系和跨学科工作方式。总体而言，我们预计此次合作的成果将大大提高对寄生虫如何引起疾病的了解，以及如何利用这些知识来开发治疗利什曼病的新疗法。

项目成果

Parasite Genotype Is a Major Predictor of Mortality from Visceral Leishmaniasis.

• DOI: 10.1128/mbio.02068-22
• 发表时间: 2022-12-20
• 期刊: mBio
• 影响因子: 6.4

Genome duplication in Leishmania major relies on persistent subtelomeric DNA replication.

• DOI: 10.7554/elife.58030
• 发表时间: 2020-09-08
• 期刊: eLife
• 影响因子: 7.7
• 作者: Damasceno JD;Marques CA;Beraldi D;Crouch K;Lapsley C;Obonaga R;Tosi LR;McCulloch R
• 通讯作者: McCulloch R

Variables Influencing Differences in Sequence Conservation in the Fission Yeast Schizosaccharomyces pombe.

• DOI: 10.1007/s00239-021-10028-y
• 发表时间: 2021-12
• 期刊: Journal of molecular evolution
• 影响因子: 3.9
• 作者: Harnqvist SE;Grace CA;Jeffares DC
• 通讯作者: Jeffares DC

Toll-Like Receptor- and Protein Kinase R-Induced Type I Interferon Sustains Infection of Leishmania donovani in Macrophages.

TOLL样受体和蛋白激酶R诱导的I型干扰素持续巨噬细胞中的Leishmania Donovani感染。

• DOI: 10.3389/fimmu.2022.801182
• 发表时间: 2022
• 期刊: Frontiers in immunology
• 影响因子: 7.3
• 作者: Dias BT;Goundry A;Vivarini AC;Costa TFR;Mottram JC;Lopes UG;Lima APCA
• 通讯作者: Lima APCA

Read, Write, Adapt: Challenges and Opportunities during Kinetoplastid Genome Replication.

• DOI: 10.1016/j.tig.2020.09.002
• 发表时间: 2021-01
• 期刊: TRENDS IN GENETICS
• 影响因子: 11.4
• 作者: Damasceno, Jeziel D.;Marques, Catarina A.;Black, Jennifer;Briggs, Emma;McCulloch, Richard
• 通讯作者: McCulloch, Richard