UK-Brazil Joint Centre for Arbovirus Discovery, Diagnosis, Genomics and Epidemiology (CADDE)

英国-巴西虫媒病毒发现、诊断、基因组学和流行病学联合中心 (CADDE)

• 批准号: MR/S019510/1
• 负责人: Nuno Faria
• 金额: $ 153.22万
• 依托单位: University of Oxford
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2019
• 资助国家: 英国
• 起止时间: 2019 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=MR%2FS019510%2F1
• 关键词: UK; Brazil; Joint; Centre; Arbovirus

Recently, Brazil has been affected by unexpected and explosive epidemics of insect-transmitted viruses (arboviruses), most notably Zika, chikungunya, dengue, and yellow fever viruses. The huge economic burden of the Zika epidemic in Brazil and the widespread presence of urban mosquitos in the country highlight an urgent need for accurate predictions of disease spread, particularly in large, densely populated regions. Our UK-Brazil Partnership (CADDE) will enhance and expand an excellent existing collaborations, with the aim of anticipating and controlling future epidemics of arboviruses in Brazil. It is our vision for CADDE to become a strategic centre of excellence for research in South America that focuses on providing timely analysis, based on genomic, epidemiological and geographic evidence, to anticipate and control transmission of arboviruses, today and in the future.. Our research questions include: 1) What arboviruses circulate in human, mosquito and reservoir populations in Brazil? 2) Where and how do arboviruses persist during non-epidemic periods? 3) What are the biological and medical implications of the genetic diversity of circulating arboviruses and of mutations in their genomes? 4) What factors control the transformation of a single introduction of a new arbovirus into human populations into sizeable epidemic, and 5) how quickly can we detect and characterise such epidemics, and how best to respond? Active virus surveillance in vectors and reservoirs will be combined with seroprevalence surveys in blood donors (to characterise features such as virus genomics, transmission, and immunity). Novel portable genome sequencing technologies and modern real-time epidemiological analyses will be applied to the most important arboviruses in Brazil. Using modern techniques that can unify the information from genomics and epidemiology, CADDE will strengthen the evidence base for public health actions, and strengthen the capacity of Brazilian health system to respond to emerging arboviral diseases. We will transform local capacity by training research scientists and public health personnel in field epidemiology, laboratory testing, the use of portable genomic technologies, and computational and statistical methods.

最近，巴西受到昆虫传播病毒（虫媒病毒）意外爆发性流行的影响，其中最著名的是寨卡病毒、基孔肯雅病毒、登革热病毒和黄热病病毒。巴西寨卡疫情造成的巨大经济负担以及该国城市蚊子的广泛存在，凸显了准确预测疾病传播的迫切需要，特别是在人口稠密的大片地区。我们的英国-巴西合作伙伴关系（CADDE）将加强和扩大现有的良好合作，旨在预测和控制未来虫媒病毒在巴西的流行。我们的 CADDE 愿景是成为南美洲卓越的战略研究中心，专注于根据基因组、流行病学和地理证据提供及时分析，以预测和控制当前和未来的虫媒病毒传播。我们的研究问题包括：1) 巴西的人类、蚊子和宿主种群中传播哪些虫媒病毒？ 2）非流行期间虫媒病毒在哪里以及如何持续存在？ 3) 传播的虫媒病毒的遗传多样性及其基因组突变有何生物学和医学意义？ 4) 哪些因素控制着一种新的虫媒病毒在人群中的单次引入转变为大规模流行病，以及 5) 我们能够多快地检测和描述此类流行病，以及如何最好地应对？对媒介和储存者的主动病毒监测将与献血者的血清阳性率调查相结合（以表征病毒基因组学、传播和免疫等特征）。新型便携式基因组测序技术和现代实时流行病学分析将应用于巴西最重要的虫媒病毒。 CADDE 将利用能够统一基因组学和流行病学信息的现代技术，加强公共卫生行动的证据基础，并增强巴西卫生系统应对新出现的虫媒病毒疾病的能力。我们将通过在现场流行病学、实验室检测、便携式基因组技术的使用以及计算和统计方法方面培训研究科学家和公共卫生人员来转变当地能力。

项目成果

Respiratory Viral Shedding in Healthcare Workers Reinfected with SARS-CoV-2, Brazil, 2020.

• DOI: 10.3201/eid2706.210558
• 发表时间: 2021
• 期刊: Emerging infectious diseases
• 影响因子: 11.8
• 作者: Amorim MR;Souza WM;Barros ACG Jr;Toledo-Teixeira DA;Dos-Santos KB;Simeoni CL;Parise PL;Vieira A;Forato J;Claro IM;Mofatto LS;Barbosa PP;Brunetti NS;França ESS;Pedroso GA;Carvalho BFN;Zaccariotto TR;Krywacz KCS;Vieira AS;Mori MA;Farias AS;Pavan MHP;Bachur LF;Cardoso LGO;Spilki FR;Sabino EC;Faria NR;Santos MNN;Angerami R;Leme PAF;Schreiber A;Moretti ML;Granja F;Proenca-Modena JL
• 通讯作者: Proenca-Modena JL

Landscape connectivity for yellow fever: a proxy approach to detect displacement and circulation through environmental corridors and interfaces

黄热病的景观连通性：通过环境走廊和界面检测位移和循环的代理方法

• DOI: 10.1016/s2542-5196(21)00106-6
• 发表时间: 2021
• 期刊: The Lancet Planetary Health
• 作者: Acosta A

Interfaces à transmissão e spillover do coronavírus entre florestas e cidades

花卉和城市中冠状病毒的传播和溢出的接口

• DOI: 10.1590/s0103-4014.2020.3499.012
• 发表时间: 2020
• 期刊: Estudos Avançados
• 作者: ACOSTA A

Global disparities in SARS-CoV-2 genomic surveillance.

• DOI: 10.1038/s41467-022-33713-y
• 发表时间: 2022-11-16
• 期刊: Nature communications
• 影响因子: 16.6

First Report of Wenzhou sobemo-like virus 4 in Aedes albopictus (Diptera: Culicidae) in Latin America.

• DOI: 10.3390/v14112341
• 发表时间: 2022-10-25
• 期刊: Viruses
• 作者: Andrade PS;Valença IN;Heinisch MRS;Rocha EC;Fernandes LN;Faria NR;Sabino EC;Lima-Camara TN
• 通讯作者: Lima-Camara TN