IDENTIFICATION OF CANDIDATE GENE POLYMORPHISMS THAT INFLUENCE PROGRESSION TO AIDS

HIV-1感染人群的变异特征 世界人口表明， 相关基因的多态性可能是重要的。多态性 在趋化因子受体中， on both都infection感染and the rate率ofprogression进展to AIDS艾滋病in Caucasians白人. 在已报道的三种保护性等位基因中，CCR 5-delta 32，CCR 2 - 64 I， 和SDF 1 - 3 'A，只有CCR 2 - 64 I在非洲裔美国人中常见， 非洲原住民，但它似乎没有那么保护， 白人。我们已经确定了HIV-1的几个多态性 候选基因的出现频率很高， 非裔美国人初步分析显示 趋化因子受体基因之间复杂的相互作用， 一组非洲人对疾病进展的易感性增加 美国人我们也在鉴定 高加索人和非裔美国人都有宿主基因 编码蛋白质，包括转录因子编码蛋白质，包括转录因子 参与入境后的事件。其中几种多态性 现在正在筛选它们对感染和进展的影响， 候选基因的鉴定 影响艾滋病进展的多态性

The variable character of the HIV-1 epidemicamong world populations suggests that racial distribution of polymorphisms for relevantgenes may be important. Polymorphisms in chemokine receptors have been shown to have aprofound effect on both infection and the rate ofprogression to AIDS in Caucasians. Of thethree protective alleles reported, CCR5-delta32,CCR2-64I, andSDF1-3'A, only CCR2-64I iscommon in African-Americans or native Africans,but it appears to be less protective than inCaucasians. We have identified severalpolymorphisms in HIV-1 candidate genes that occurwith high frequency in African-Americans.Preliminary analyses suggest that there may be complex interactions between chemokine receptorgenes that increase susceptibility to diseaseprogression in a cohort of African Americans. Weare also identifying polymorphisms in bothCaucasians and African-Americans that occur inhost genes encoding proteins, includingtranscriptional factors, that are involved inpost-entry events. Several of these polymorphismsare now being screened for their effects oninfection and progression in the two racial groups.Identification of Candidate Gene Polymorphisms that Influence Progression to AIDS