Regulation of trophoblast differentiation by BAF complex chromatin remodelling factors
BAF 复合染色质重塑因子对滋养层分化的调节
基本信息
- 批准号:MR/S021531/1
- 负责人:
- 金额:$ 58.95万
- 依托单位:
- 依托单位国家:英国
- 项目类别:Research Grant
- 财政年份:2019
- 资助国家:英国
- 起止时间:2019 至 无数据
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
The placenta is a critical organ required to maintain a healthy pregnancy. All organs are made up of many distinct cell types. In the placenta the foetus contributes a range of different highly specialized cells called "trophoblasts", which form from a single specialized cell type called Trophoblast Stem Cells (TSCs) that we can culture and study in the laboratory. Pregnancy complications such as preeclampsia, and its more severe form HELLP Syndrome affect approximately 5% of pregnancies, have potentially long-term health implications and are one of the leading causes of maternal and infant death. Defective development and behaviour of trophoblasts is heavily implicated in these pregnancy complications so understanding how trophoblasts form is critical to developing better diagnostic, treatment and management methodologies to tackle such disorders. The identity and behaviour of cells is largely controlled by the genes that are active within the cell. Whether genes are active, and thus the identity of cells, depends on whether DNA is accessible to the molecular machinery that controls gene activation. The accessibility of DNA is controlled by specialised proteins known as "chromatin remodelling factors", so these factors control trophoblast development and behaviour. In particular, previous studies suggest that the BAF complex of chromatin remodelling factors are important for the correct formation of different trophoblast types, and thus a viable pregnancy.In this project we will investigate how BAF complexes control the balance of different trophoblast types arising from TSCs, and how they interact with a network of other proteins to do so. Our research will tell us how cell fate decisions are controlled in the placenta. It will reveal proteins and DNA sequences that control trophoblast formation, and which may therefore be mutated leading to pregnancy complications. The ultimate result will therefore be key advances in our fundamental understanding of how the placenta develops. This new knowledge can be exploited in future to develop therapeutic intervention strategies in pregnancy disorders that are associated with problems of placental function.
胎盘是维持健康妊娠所需的重要器官。所有器官都是由许多不同的细胞类型组成的。在胎盘中,胎儿贡献了一系列不同的高度特化的细胞,称为“滋养层”,它们由一种称为滋养层干细胞(TSCs)的单一特化细胞类型形成,我们可以在实验室中培养和研究。妊娠并发症,如先兆子痫及其更严重的HELLP综合征影响约5%的妊娠,具有潜在的长期健康影响,是孕产妇和婴儿死亡的主要原因之一。滋养层细胞的发育和行为缺陷与这些妊娠并发症密切相关,因此了解滋养层细胞如何形成对于开发更好的诊断,治疗和管理方法来解决这些疾病至关重要。 细胞的特性和行为在很大程度上由细胞内活跃的基因控制。基因是否活跃,以及细胞的身份,取决于控制基因激活的分子机制是否能接近DNA。DNA的可及性由称为“染色质重塑因子”的专门蛋白质控制,因此这些因子控制滋养层发育和行为。特别是,以前的研究表明,BAF复合物的染色质重塑因子是重要的正确形成不同的滋养层类型,从而一个可行的pregnancy.In这个项目中,我们将研究如何BAF复合物控制的平衡不同的滋养层类型所产生的TSCs,以及他们如何与其他蛋白质的网络这样做。我们的研究将告诉我们细胞命运的决定是如何在胎盘中控制的。它将揭示控制滋养层形成的蛋白质和DNA序列,因此可能会发生突变,导致妊娠并发症。因此,最终的结果将是我们对胎盘如何发育的基本理解的关键进展。这一新的知识可以在未来开发与胎盘功能问题相关的妊娠疾病的治疗干预策略。
项目成果
期刊论文数量(1)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Eomes function is conserved between zebrafish and mouse and controls left-right organiser progenitor gene expression via interlocking feedforward loops.
- DOI:10.3389/fcell.2022.982477
- 发表时间:2022
- 期刊:
- 影响因子:5.5
- 作者:
- 通讯作者:
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Andrew Nelson其他文献
Addressing pandemic-wide systematic errors in the SARS-CoV-2 phylogeny
解决 SARS-CoV-2 系统发育中大流行范围内的系统错误
- DOI:
10.1101/2024.04.29.591666 - 发表时间:
2024 - 期刊:
- 影响因子:0
- 作者:
Martin Hunt;Angie Hinrichs;Daniel Anderson;Lily Karim;Bethany L Dearlove;Jeff Knaggs;B. Constantinides;Philip W. Fowler;G. Rodger;Teresa Street;S. Lumley;Hermione Webster;T. Sanderson;Christopher Ruis;N. de Maio;L. Amenga;D. Amuzu;M. Avaro;G. Awandare;Reuben Ayivor;M. Bashton;Elizabeth M Batty;Yaw Bediako;Denise De Belder;Estefania Benedetti;A. Bergthaler;Stefan A. Boers;Josefina Campos;Rosina Afua Ampomah Carr;Facundo Cuba;M. E. Dattero;W. Dejnirattisai;A. Dilthey;K. Duedu;L. Endler;Ilka Engelmann;Ngiambudulu M Francisco;Jonas Fuchs;Etienne Z. Gnimpieba;S. Groc;Jones Gyamfi;Dennis Heemskerk;Torsten Houwaart;N. Hsiao;Matthew Huska;Martin Hölzer;A. Iranzadeh;Hanna Jarva;C. Jeewandara;B. Jolly;R. Joseph;Ravi Kant;Karrie Ko Kwan Ki;S. Kurkela;Maija Lappalainen;Marie Lataretu;Chang Liu;G. Malavige;T. Mashe;J. Mongkolsapaya;Brigitte Montes;Jose Arturo Molina Mora;C. Morang’a;Bernard Mvula;Niranjan Nagarajan;Andrew Nelson;Joyce M. Ngoi;Joana Paula da Paixão;M. Panning;Tomás Poklépovich;Peter K. Quashie;D. Ranasinghe;Mara L Russo;J. E. San;Nicholas D Sanderson;V. Scaria;Gavin R. Screaton;T. Sironen;Abay Sisay;Darren Smith;T. Smura;P. Supasa;Chayaporn Suphavilai;J. Swann;H. Tegally;Bryan Tegomoh;Olli Vapalahti;Andreas Walker;Robert J Wilkinson;Carolyn Williamson;Tulio de Oliveira;Timothy E. A. Peto;Derrick Crook;Russell Corbett;Zam Iqbal - 通讯作者:
Zam Iqbal
On the Efficacy of Post-Build Thermomechanical Treatments to Improve Properties of Zirconium Fabricated using Ultrasonic Additive Manufacturing
构建后热机械处理对改善超声波增材制造制造的锆性能的功效
- DOI:
- 发表时间:
2022 - 期刊:
- 影响因子:11
- 作者:
C. Massey;M. Gussev;Cody Havrilak;R. Seibert;E. Cakmak;Andrew Nelson - 通讯作者:
Andrew Nelson
From Romance to Tragedy: House Ownership and Relocation in the Resettlement Narratives of Nepali Bhutanese Refugees
从浪漫到悲剧:尼泊尔不丹难民安置叙事中的房屋所有权和搬迁
- DOI:
10.1093/jrs/feaa079 - 发表时间:
2020 - 期刊:
- 影响因子:1.7
- 作者:
Andrew Nelson - 通讯作者:
Andrew Nelson
Empirical assessments of small-scale ecosystem service flows in rural mosaic landscapes in the Ethiopian highlands
埃塞俄比亚高地乡村马赛克景观小规模生态系统服务流的实证评估
- DOI:
- 发表时间:
2024 - 期刊:
- 影响因子:7.6
- 作者:
Tegegne Molla Sitotaw;L. Willemen;Derege Tsegaye Meshesha;Andrew Nelson - 通讯作者:
Andrew Nelson
978 CTNNB1 Mutation and L1CAM Expression are Not Mutually Exclusive in Endometrial Cancer
978 CTNNB1 突变与 L1CAM 表达在子宫内膜癌中并非相互排斥
- DOI:
10.1016/j.labinv.2024.103212 - 发表时间:
2025-03-01 - 期刊:
- 影响因子:4.200
- 作者:
Dina El-Rayes;Lynn Messersmith;Liberty Bonestroo;Sandhyarani Dasaraju;Elizabeth Ferreira;Andrew Nelson;Mahmoud Khalifa - 通讯作者:
Mahmoud Khalifa
Andrew Nelson的其他文献
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{{ truncateString('Andrew Nelson', 18)}}的其他基金
Collaborative Research: Mechanisms of differentiation and morphogenesis of the ligule/auricle hinge
合作研究:叶舌/耳廓铰链的分化和形态发生机制
- 批准号:
2120131 - 财政年份:2021
- 资助金额:
$ 58.95万 - 项目类别:
Standard Grant
TRTech-PGR: Identification and characterization of stress-responsive and evolutionary conserved epitranscriptomic modification sites in plant transcriptomes.
TRTech-PGR:植物转录组中胁迫响应和进化保守的表观转录组修饰位点的鉴定和表征。
- 批准号:
2023310 - 财政年份:2020
- 资助金额:
$ 58.95万 - 项目类别:
Continuing Grant
MINE-PGR: Mining public RNA-seq data to identify and annotate long non-coding RNAs in fifteen diverse angiosperms
MINE-PGR:挖掘公共 RNA-seq 数据以识别和注释 15 种不同被子植物中的长非编码 RNA
- 批准号:
2021753 - 财政年份:2019
- 资助金额:
$ 58.95万 - 项目类别:
Standard Grant
Phase III IUCRC at University of Idaho: Center for Advanced Forestry Systems
爱达荷大学 IUCRC 第三阶段:先进林业系统中心
- 批准号:
1916699 - 财政年份:2019
- 资助金额:
$ 58.95万 - 项目类别:
Continuing Grant
MINE-PGR: Mining public RNA-seq data to identify and annotate long non-coding RNAs in fifteen diverse angiosperms
MINE-PGR:挖掘公共 RNA-seq 数据以识别和注释 15 种不同被子植物中的长非编码 RNA
- 批准号:
1758532 - 财政年份:2018
- 资助金额:
$ 58.95万 - 项目类别:
Continuing Grant
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