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OPTIMIZATION OF HYPERTHERMIA--CLINIC, BIOLOGY, & PHYSICS

OPTIMIZATION OF HYPERTHERMIA--CLINIC, BIOLOGY, & PHYSICS
热疗的优化——临床、生物学、
批准号:
2712558
负责人:
STUART Keith CALDERWOOD
金额:
$170.57万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
1992
资助国家:
美国
项目状态:
已结题
起止时间:
1992-09-30 至 2001-05-31

项目摘要

项目成果

STUART Keith CALDERWOOD的其他基金

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中文摘要
翻译
本项目将采用以疾病现场为导向的方法来解决
英文摘要
This program project will use a disease-site oriented approach to address the hypothesis: hyperthermia delivered as an adjuvant to radiation therapy will improve the clinical outcome of patients with prostate cancer resulting in organ preservation, a reduced probability of recurrence, improved quality of life and superior survival. Three Projects and three Cores will bring together technical, biological and clinical expertise to focus on prostate cancer hyperthermia. The proper understanding of the clinical results, whether or not they are positive, requires relating athe technical parameters of the hyperthermia treatment with basic hyperthermia biology using the appropriate tumor systems. (Bernstein 0018). Clinical Project will deliver hyperthermia to patients with prostate cancer using the ultrasound probe developed by our collaborator, De. Hynynen. Temperature and perfusion will be measured using the profilometer probes developed in this grant. A second clinical goal is to complete testing of the Focused Segmented Ultrasound machine developed in the previous grant period. A third clinical research effort will be the continued clinical evaluation of hyperthermia modifiers (initially the hypoxia modifiers) designed to enhance the efficacy of temperatures obtainable ina the clinic. (Calderwood 0019). Biology Project is focused on prostate cancers using cells, tumor models and clinical biopsies to further the understanding of clinical results. In addition to the hyperthermia modifiers already developed for Project 1 the new classes of agents to be studied are the non-steroidal antiinflammatory agents and kinase inhibitors. (Newman 0017). Technology Project will develop the models and techniques required to allow hyperthermia to be used conveniently and routinely in the clinic, focusing on the use of perfusion data to adjust power deposition so that tahe targeted temperature can be maintained. (Svensson 9001). Technical, supports the clinical trials and the modeling efforts; (Teicher 9002). Animals, includes both small animals for the biologic experiments and large animals for testing the models/ and Administration, provides statistical support and provides external advice. In summary, this is a disease-site oriented program which has the long-term aim of answering the question of whether or not hyperthermia is an effective adjunctive therapy to radiation therapy for patients with cancer of the prostate.
期刊论文(53)
专著(0)
科研奖励(0)
会议论文
DOI: --
发表时间: 1995
期刊: Cancer research
影响因子: 11.2
作者: [J. Eder;V. Chan;S. Ng;N. Rizvi;S. Zacharoulis;B. Teicher;L. Schnipper]
通讯作者: J. Eder;V. Chan;S. Ng;N. Rizvi;S. Zacharoulis;B. Teicher;L. Schnipper
Validation of real-time continuous perfusion measurement.
实时连续灌注测量的验证。
DOI: 10.1007/bf02347053
发表时间: 2000
期刊: Medical & biological engineering & computing
影响因子: 3.2
作者: [Martin,GT, Bowman,HF]
通讯作者: Bowman,HF
Heat shock factor-1 and the heat shock cognate 70 protein associate in high molecular weight complexes in the cytoplasm of NIH-3T3 cells.
热休克因子 1 和热休克同源 70 蛋白在 NIH-3T3 细胞细胞质中的高分子量复合物中结合。
DOI: 10.1006/bbrc.1995.2090
发表时间: 1995
期刊: Biochemical and biophysical research communications
影响因子: 3.1
作者: [Nunes,SL, Calderwood,SK]
通讯作者: Calderwood,SK
Advanced ultrasonic techniques for local tumor hyperthermia.
用于局部肿瘤热疗的先进超声技术。
DOI: --
发表时间: 1989
期刊: Radiologic clinics of North America
影响因子: 1.9
作者: [Lele,PP]
通讯作者: Lele,PP
19
    Complex Role of HSF1 in Breast Cancer
    Complex Role of HSF1 in Breast Cancer
    Complex Role of HSF1 in Breast Cancer
    Extracellular Hsp70 and hyperthermia in tumor therapy
    海外基金