OPIOID INVOLVEMENT IN ALCOHOL DRINKING

描述：本研究计划涉及以下假设： 酒精诱导的阿片系统激活是一种神经生物学 导致大量饮酒的机制。 这个目标 建议是确定受体选择性阿片拮抗剂是否 能够阻断高酒精饮用的开始和维持 对酒精偏好进行选择性饲养的老鼠。 为了实现这一目标， 具体目标如下：1. 确定是否为慢性 单独施用μ和δ受体选择性拮抗剂， 结合，减弱饮酒后，饮酒已开始在大鼠 有选择性地培育出的酒精偏好。 2. 确定长期服用mu或delta 受体选择性拮抗剂可防止再次饮酒 在大鼠选择性停止慢性消耗（复发）后 因酗酒而长大 3. 确定长期服用mu或delta 受体选择性拮抗剂可防止饮酒的开始， 根据酒精偏好选择性饲养的老鼠。 拟议的实验将确定mu和delta的效力 受体选择性拮抗剂在减少酒精摄入和意志 确定这些拮抗剂是否主要减少酒精的摄入量 与食物、水和另一种首选解决方案的摄入相比。 实验将使用酒精偏好（P）的大鼠进行。 和高酒精饮用（HAD）线，非常适合测试 有可能减少酒精摄入量的药物的功效。

DESCRIPTION: This research plan addresses the hypothesis that alcohol-induced activation of the opioid system is a neurobiological mechanism that contributes to high alcohol drinking. The goal of this proposal is to determine whether receptor-selective opioid antagonists are capable of blocking the initiation and maintenance of high alcohol drinking in rats selectively bred for alcohol preference. To achieve this goal the following specific aims will be pursued: 1. Determine whether chronic administration of a mu and a delta receptor-selective antagonist, alone and in combination, attenuates alcohol drinking after drinking has begun in rats selectively bred for alcohol preference. 2. Determine whether chronic administration of a mu or a delta receptor-selective antagonist prevents reinitiation of alcohol drinking following cessation of chronic consumption (relapse) in rats selectively bred for alcohol preference. 3. Determine whether chronic administration of a mu or a delta receptor-selective antagonist prevents the initiation of alcohol drinking in rats selectively bred for alcohol preference. The proposed experiments will determine the potency of mu and delta receptor-selective antagonists in attenuating alcohol intake and will determine whether these antagonists primarily reduce the intake of alcohol compared with the intake of food, water, and another preferred solution. The experiments will be conducted using rats of the alcohol-preferring (P) and high alcohol drinking (HAD) lines which are well suited for testing the efficacy of agents that have the potential to reduce alcohol intake.