ETS GENES AND TRANSFORMATION AND DIFFERENTIATION

ETS 基因以及转化和分化

• 批准号: 2827256
• 负责人: TAKIS S PAPAS
• 金额: $ 92.44万
• 依托单位: MEDICAL UNIVERSITY OF SOUTH CAROLINA
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-09-30 至 2003-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2827256
• 关键词: cell differentiation; cell growth regulation; genetic regulation; neoplasm /cancer genetics; transcription factor

The overall goal of this Program Project is to understand how the ets gene family functions in the regulation of cellular growth, differentiation and transformation. Family members play an important role in hematopoiesis, angiogenesis and vascular development. That the ets genes have a role in cancer was first suggested by the presence of ets sequences found in the oncogenic virus, E26. Family members are located in chromosomal regions associated with certain leukemias, Down Syndrome and retroviral induced cancers. The ets genes are transcriptional factors, have independent activities and are likely to constitute a fundamental integrated regulatory network. The precise interplay among the members of this network has not as yet been elucidated. Although considerable work has been done the individual family members, no coherent efforts have been made to fully understand the functional inter-relationships among the family members. This Program Project proposes to study the interplay among these genes, and the key questions to be addressed are, 1) why do the ets genes occur as a family? What are the functional redundancies among the family members? ii) what other regulatory proteins interact with each family member? Does each ets gene family member interact with unique or common proteins? iii) What are the target genes for each family member? Are these target genes regulated by single or multiple members of the ets family? iv) In what signal transduction pathway are the ets genes family members involved? v) What are the roles of ets family members in oncogenesis, tumor suppressor and aberrant development? This Program Project focuses on studies of ETS1 and FLI1 cloned and characterized extensively studied by the principal Investigator and his collaborating PI's. These genes are representatives of the entire ets gene family, and their study will expand our knowledge of the function of the entire family.

该计划项目的总体目标是了解 ets 基因如何 家族在调节细胞生长、分化和 转变。家庭成员在造血过程中发挥着重要作用， 血管生成和血管发育。 ets 基因的作用 癌症最初是由在 致癌病毒，E26。家庭成员位于染色体区域 与某些白血病、唐氏综合症和逆转录病毒诱导的 癌症。 ets基因是转录因子，具有独立的 活动并可能构成基本的综合 监管网络。该组织成员之间的精确相互作用 网络尚未阐明。尽管已经开展了大量工作 个别家庭成员已经做了，但没有做出一致的努力 充分理解各功能之间的相互关系 家庭成员。该计划项目建议研究之间的相互作用 这些基因，需要解决的关键问题是，1）为什么 ets 基因作为一个家族出现？各部门之间存在哪些职能冗余？ 家庭成员？ ii) 还有哪些其他调节蛋白与每个蛋白相互作用 家属？每个 ets 基因家族成员是否与独特的或 常见蛋白质？ iii) 每个家庭成员的目标基因是什么？ 这些靶基因是由 ets 的单个或多个成员调控的吗？ 家庭？ iv) ets 基因家族属于什么信号转导途径 成员参与？ v) ets 家族成员在其中扮演什么角色 肿瘤发生、肿瘤抑制和异常发育？本计划 项目重点研究 ETS1 和 FLI1 的克隆和表征 首席研究员及其合作者进行了广泛研究 PI 的。这些基因是整个ets基因家族的代表，并且 他们的研究将扩大我们对整个系统功能的了解 家庭。