LIBRARIES OF AMINOGLYCOSIDES AND MIMETICS TARGETING RNA

氨基糖苷类化合物文库及其RNA靶向模拟 该项目将采取合理的组合方式进行开发 氨基糖苷类化合物及其靶向癌症相关RNA的模拟物 血管生成。它将重点关注以下计划： 1.1.我们发现1，3-羟胺的活性要好于胍 以基团为识别基序的磷酸二酯和 核糖核酸中鸟苷的Hoogsteen脸。我们将利用这个新的主题作为 核心开发小分子文库以筛选抑制剂(使用 表面等离子激元共振)靶向RNA和整合素 癌症和血管生成。 2.反应性基团或短反义脱氧寡核苷酸的连接 以开发序列选择性RNA裂解剂的领先候选。 在生物医学、药物设计、药物 抗性、合成有机化学和一种新的 新一代抗癌药物有望问世。

Libraries of aminoglycosides and mimetics targeting RNA This project will take rational and combinatorial approaches to develop aminoglycosides and mimetics targeting cancer-associated RNA as well as angiogenesis. It will focus on the following programs: 1. We have discovered that 1,3-hydroxyamines are better than the guanidine groups as recognition motif for the complexation of phosphodiesters and the Hoogsteen face of guanosine in RNA. We will use this new motif as a core to develop small-molecule libraries to screen for inhibitors (using surface plasmon resonance) targeting RNAs and integrins associated with cancer and angiogenesis. 2. Attachment of reactive groups or short antisense deoxyoligonucleotides to the lead candidates to develop sequence selective RNA cleaving agents. Significant contributions in the areas of biomedicine, drug design, drug resistance, synthetic organic chemistry and the discovery of a new generation of anti-cancer agents are expected.