LIBRARIES OF AMINOGLYCOSIDES AND MIMETICS TARGETING RNA

靶向RNA的氨基糖苷类化合物及其模拟物文库 该项目将采取合理和组合的方法来开发 靶向癌症相关RNA的氨基糖苷类和模拟物，以及 血管生成它将侧重于以下方案： 1.我们已经发现1，3-羟胺比胍更好 基团作为磷酸二酯络合的识别基序， RNA中鸟苷的Hoogsteen面孔。我们将使用这个新的主题作为一个 核心开发小分子库筛选抑制剂（使用 表面等离子体共振）靶向RNA和与 癌症和血管生成。 2.反应基团或短反义脱氧寡核苷酸的连接 开发序列选择性RNA切割剂的主要候选人。 在生物医学、药物设计、药物代谢、药物代谢等领域做出了重要贡献。 耐药性，合成有机化学和发现一种新的 抗癌剂的产生是预期的。

Libraries of aminoglycosides and mimetics targeting RNA This project will take rational and combinatorial approaches to develop aminoglycosides and mimetics targeting cancer-associated RNA as well as angiogenesis. It will focus on the following programs: 1. We have discovered that 1,3-hydroxyamines are better than the guanidine groups as recognition motif for the complexation of phosphodiesters and the Hoogsteen face of guanosine in RNA. We will use this new motif as a core to develop small-molecule libraries to screen for inhibitors (using surface plasmon resonance) targeting RNAs and integrins associated with cancer and angiogenesis. 2. Attachment of reactive groups or short antisense deoxyoligonucleotides to the lead candidates to develop sequence selective RNA cleaving agents. Significant contributions in the areas of biomedicine, drug design, drug resistance, synthetic organic chemistry and the discovery of a new generation of anti-cancer agents are expected.