Development of gene-activated scaffolds as bone bioreactor for bone regeneration and osteointegration

据估计，全球骨替代品市场每年超过10亿美元。新兴的细胞治疗技术为骨缺损的治疗打开了一扇新的窗口。该项目旨在开发能够诱导血管形成的基因活化支架，从而改善局部营养供应，并随后刺激骨缺损中的骨形成以及植入物表面周围的骨整合。该项目产生的知识将有助于治疗一些整形外科和牙科疾病。

The worldwide market for bone substitutes has been estimated at over US $1 billion annually. The emerging technology of cell based therapy has opened a new window for the treatment of bone defects. This project is to develop gene-activated scaffolds able to induce blood vessel formation thus improving the local nutrition supply, and subsequently stimulating bone formation in bone defects, as well as osteointegration around implant surface. The knowledge generated from this project will help the treatment of a number of orthopaedic and dental conditions.