课题基金 / 基金详情

CARBOHYDRATE DEPENDENT ADHESION OF NORMAL & TUMOR CELLS

CARBOHYDRATE DEPENDENT ADHESION OF NORMAL & TUMOR CELLS
碳水化合物依赖性正常粘附力
批准号:
2700702
负责人:
MINORU FUKUDA
金额:
$127.66万
依托单位国家:
美国
项目类别:
财政年份:
1996
资助国家:
美国
项目状态:
已结题
起止时间:
1996-07-08 至 2001-04-30

项目摘要

项目成果

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中文摘要
翻译
这个项目研究了结构,生物合成和作用
英文摘要
This program project examines the structure, biosynthesis, and roles of selectin ligands in cell-cell communication. It also aims at elucidating the roles of the selectin-carbohydrate interaction in tumor cell metastasis. This program project is a close collaboration among investigators whose expertise range from carbohydrate synthetic chemistry, carbohydrate chemistry, carbohydrate biosynthesis, to cellular and molecular biology. The work centers around the sialyl Lex and related oligosaccharide structures originally discovered by the participants in this grant as E- selectin ligands. Structure and biosynthesis of E-, P- and L-selectin ligands in human and mice will be investigated. In particular, the roles of specific fucosyltransferase(s) in the formation of selectin ligands and those of N-glycans presenting selectin ligands will be determined by using knock-out mice. In addition, the structure and biosynthesis of the oligosaccharide L-selectin ligand(s) will be elucidated by cloning an enzyme that forms the ligand(s). The regulation of selectin ligand biosynthesis will be investigated in relation to subcellular localization of the enzymes involved in the biosynthesis of selectin ligands. This program project also aims at determining the roles of selectin-mediated adhesion in tumor cell dissemination. These studies will provide new information on selectin-carbohydrate interactions and may help in the design of improved therapeutic intervention in malignancies and other diseases.
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会议论文
Carbohydrate Antigenic Biomarkers for Epithelial Cancers
Carbohydrate Antigenic Biomarkers for Epithelial Cancers
Roles of Sulfated Glycans in Lymphocyte Recruitment and Tumor Angiogenesis
Administration
国内基金
海外基金
GMFG/F-actin/cell adhesion 轴驱动 EHT 在造 血干细胞生成中的作用及机制研究
  • 批准号:
    TGY24H080011
  • 项目类别:
    省市级项目
  • 资助金额:
    --
  • 批准年份:
    2024
  • 负责人:
    李鸿鹄
  • 依托单位: