Carbohydrate-Dependent Adhesion in Normal and Tumor Cells

正常细胞和肿瘤细胞中碳水化合物依赖性粘附

• 批准号: 7915830
• 负责人: MINORU FUKUDA
• 金额: $ 33.11万
• 依托单位: SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-08-01 至 2011-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7915830
• 关键词: Carbohydrate; Dependent; Adhesion; Normal; Tumor

DESCRIPTION (provided by applicant): This program project examines the structure, biosynthesis, and roles of carbohydrates in cell-cell interaction. The proposed projects were borne-out from our strong collaborative research activities in the previous funding period. This program project is a continued close collaboration among investigators whose expertise ranges from carbohydrate synthetic chemistry, carbohydrate biosynthesis, immunology, to cellular and molecular biology. In the coming years, we will add strength in research capability by incorporating intravital microscopy to observe migrating and interacting cells in vivo. The work centers around sulfated, fucosylated glycoconjugates in lymphocyte trafficking, tumor progression, and myelopoiesis. The work includes the role of carbohydrate-mediated signal transduction, a novel aspect in the field, through studies on the role of fucose in Notch signaling. The work also determines the role of carbohydrate-dependent tumor metastasis by identifying novel carbohydrate recognition molecules and their use for tumor targeting, and determining the roles of heparan sulfate in tumor angiogenesis. These studies will provide new information on the roles of carbohydrates in myelopoiesis, chronic inflammation, tumor progression, and carbohydrate-dependent signal transduction. The knowledge gained from these studies may help in the design of improved therapeutic intervention against malignancies and other diseases.

描述（由申请人提供）：该程序项目研究了碳水化合物在细胞 - 细胞相互作用中的结构，生物合成和作用。拟议的项目是从上一期资金期间的强大协作研究活动中揭示的。该计划项目是研究人员之间持续的密切合作，其专业知识范围从碳水化合物合成化学，碳水化合物生物合成，免疫学到细胞和分子生物学。在接下来的几年中，我们将通过纳入内室显微镜来观察体内迁移和相互作用的细胞来增加研究能力。该工作围绕淋巴细胞贩运，肿瘤进展和骨髓病的硫化糖基化的糖基二轭物。这项工作包括碳水化合物介导的信号转导的作用，这是田间新方面，通过研究岩藻糖在Notch信号传导中的作用。这项工作还通过鉴定新型的碳水化合物识别分子及其用于肿瘤靶向的用途，并确定硫酸乙酰肝素在肿瘤血管生成中的作用，从而决定了碳水化合物依赖性肿瘤转移的作用。这些研究将提供有关碳水化合物在骨髓，慢性炎症，肿瘤进展和碳水化合物依赖性信号转导的作用的新信息。从这些研究中获得的知识可能有助于设计改善针对恶性肿瘤和其他疾病的治疗干预措施。