ESTIMATION, IMAGING, AND PERCEPTION OF TISSUE ELASTICITY

弹性成像提供了诊断成像的新机会 疾病，特别是癌症的检测和特征，通过 利用组织弹性的变化，几乎所有 癌变的病变。这个项目的总体目标是探索方法 以生成、解释和评估弹性图。该计划包括 三个项目和三个核心。项目1将由Dr。 来自蒙特利尔大学的伯特兰。该项目旨在开发一种 描述二维和三维组织运动的计算机模型 弹性成像的形成过程。主要目标是 了解弹性介质对外加应力的响应，从而 指导数据采集以获得准确的应变估计和最小化 制造艺术品的扭曲。项目2将由奥菲尔博士执导 来自德克萨斯大学。该项目旨在寻找最优的 用于弹性成像的信号处理技术。图像 决定灵敏度、动态范围、分辨率、 对比度和噪声将从妥协的角度进行调查 最大限度地提高任务绩效所必需的。图像伪影分析 还将研究将它们降至最低或消除的方法。 最后，在体外研究中，测量正常和 病理性的乳腺和前列腺组织将通过 转包给贝勒医学院的Krouskop博士。项目3将 由堪萨斯大学的Insana博士执导。该项目的目标是 制定评价弹性成像图像质量的客观标准 在低对比度可探测性方面。一项统计分析 将进行弹性图，并提供更多的改进 完整的组织运动研究(项目1)和更好的成像 将通过评估视觉检测来评估策略(项目2) 效率。CORE 9001，由加州大学的霍尔博士执导 堪萨斯州将建立和维护数据流的基本通信 在实验室之间。同样由霍尔博士执导的CORE 9002将开发 并构建所有必需的超声和弹性图模体 三个项目。由奥菲尔博士指导的CORE 9003将提供 使用模型和组织的弹性成像数据和图像 UT实验室和诊所独有的专用设备。这个 整个项目的重点是乳房的检测和特征 和前列腺癌。

Elastography provides new opportunities in diagnostic imaging for the detection and characterization of disease, particularly cancer, by exploiting the changes in tissue elasticity that occur in nearly all cancerous lesions. The overall goal of this program is to explore methods to generate, interpret, and evaluate elastograms. The program consists of three projects and three cores. Project 1 will be directed by Dr. Bertrand from the University of Montreal. The project aims to develop a computer model of two- and three- dimensional tissue motion to describe the elastographic image formation process. The principal goal is to understand the response of elastic media to an applied stress, and thereby guide data acquisition to obtain accurate strain estimates and minimize artifact-producing distortions. Project 2 will be directed by Dr. Ophir from the University of Texas. The project aims to search for optimal signal processing techniques for elastographic image formation. Image quality factors that determine sensitivity, dynamic range, resolution, contrast, and noise will be investigated in terms of the compromises necessary to maximize task performance. An analysis of image artifacts and methods to minimize or eliminate them will also be investigated. Finally, in vitro studies to measure the elastic properties of normal and pathological breast and prostate tissues will be conducted through a subcontract to Dr. Krouskop at Baylor College of Medicine. Project 3 will be directed by Dr. Insana from the University of Kansas. The project aims to develop objective criteria for evaluating elastographic image quality in terms of low-contrast detectability. A statistical analysis of elastograms will be conducted, and improvements provided by a more complete study of tissue motion (project 1) and better image formation strategies (project 2) will be evaluated by estimating visual detection efficiencies. Core 9001, directed by Dr. Hall from the University of Kansas, will establish and maintain essential communication for data flow between laboratories. Core 9002, also directed by Dr. Hall, will develop and construct sonographic and elastographic phantoms necessary in all three projects. Core 9003, directed by Dr. Ophir, will provide elastographic data and images from phantoms and tissues using the specialized equipment unique to the UT laboratories and clinics. The overall program focus in on the detection and characterization of breast and prostate cancer.