ELASTOGRAPHY: CLINICAL AND BASIC SCIENCE

弹性成像为包括癌症在内的正常和异常组织的可视化提供了新的诊断成像机会，这是通过成像许多组织中出现的组织弹性的正常分布和异常变化来实现的。我们对PPG更新应用的总体假设是，与软组织的局部弹性特性相关的横截面应变图像(弹性图)传达了重要的新信息，可以显著提高显示和解释正常和异常组织结构的能力。因此，该计划项目提案的总体目标是探索和评估最好地利用弹性成像来提高这种能力的方法，特别是在乳腺癌和前列腺癌领域。这份PPG竞争续签申请包括个人研究项目(包括分包合同)和核心；还包括一个工业合作伙伴。项目：组织位移和反问题方法的研究(M.Bertrand)，及其在前列腺成像中的应用(通过JY Chapelon分包)项目：弹性成像图像形成和弹性成像纹理的权衡研究(J.Ophir)，对于乳腺和前列腺组织的基本弹性特性(通过与T.Krouskop的分包合同)项目：活体乳房(B.Garra和C.Merritt)以及动物模型肝脏和前列腺弹性图的临床验证(与C.Merritt分包)核心：项目管理核心(J.Ophir)核心：硬件和软件开发和维护核心(F.Kallel)核心：实验室间通信核心(M.Bertrand)工业合作伙伴：Atl超声波公司已同意向PPG参与者提供四种最先进的超声设备和培训(R.Daigle)

Elastography provides new opportunities in diagnostic imaging for the visualization of normal and abnormal tissues, including cancer This is done by imaging normal distributions as well as abnormal changes in tissue elasticity that occur in many tissues. Our overall hypothesis of this PPG renewal application is that cross-sectional strain images (elastograms) that are related to the local elastic properties of soft tissues, convey important new information that could substantially increase the capability to display and interpret normal and abnormal tissue structure. The overall goal of this program project proposal is therefore to explore and evaluate the way by which elastography may best be utilized to increase this capability, especially in areas of breast and prostate cancer. This PPG competitive renewal application consists of individual research projects (with subcontracts) and cores; an industrial partner is also included. PROJECT: The study of tissue displacement and inverse problem methods (M. Bertrand), with applications to the imaging of the prostate (via subcontract with JY Chapelon) PROJECT: The study of tradeoffs in elastographic image formation and elastographic texture (J. Ophir), and for the basic elastic properties of breast and prostate tissues (via a subcontract with T. Krouskop) PROJECT: Clinical validation of elastograms in the breast in vivo (B. Garra and C. Merritt) and in liver and prostate in animal models (sib subcontract with C. Merritt) CORE: Program Administration Core (J. Ophir) CORE: Hardware and Software Development and Maintenance Core (F. Kallel) CORE: Inter-laboratory Communications Core (M. Bertrand) INDUSTRIAL PARTNER: ATL Ultrasound Corp. has agreed to supply the PPG participant with four state- of-the-art ultrasound equipment and training (R. Daigle)