BIOLOGY OF NONMELANOMA SKIN CANCER GROWTH & PROGRESSION
非黑色素瘤皮肤癌生长的生物学
基本信息
- 批准号:2882427
- 负责人:
- 金额:$ 83.57万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:1996
- 资助国家:美国
- 起止时间:1996-05-06 至 2001-07-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
The incidence of non-melanoma skin cancer (NMSC) is increasing rapidly, and
further increases are expected. A small proportion of these basal and
squamous cell carcinomas of the skin exhibit an aggressive phenotype,
characterized by multiple recurrences, size more then 2 cm, invasion of
muscle, cartilage, bone, or nerves, or lymph node metastasis. The State of
Texas has a high incidence of skin cancer and an unusually high death rate
from NMSC. Because of its geographic location and referral patterns, the
University of Texas M. D. Anderson Cancer Center treats a large number of
highly aggressive NMSC; in fact, nearly half of the approximately 100 new
cases of skin cancer seen annually in the Department of Head and Neck
Surgery exhibit aggressive behavior and are difficult to control by surgery
and radiation.
Progress toward reducing the incidence of and morbidity and mortality from
NMSC requires a 3-pronged approach; Identification of the etiologic and
genetic factors that contribute to skin cancer induction; determination of
the host and tumor characteristics associated with skin cancer
progressions; and development of new approaches for the treatment of highly
aggressive NMSC. The specific aims of this Program are therefore, to (1)
develop an understanding of the molecular events leading to skin cancer
development; (2) ascertain athe role of UV radiation in the development of
NMSC, including those with aggressive behavior, (3) assess the contribution
of various mechanisms to progression of NMSC; (4) reduce morbidity and
mortality and improve the quality of life of patients with aggressive skin
cancer.
These goals will be addressed by 16 Key Program Investigators in laboratory
and clinical investigations on the role of p53 in UV carcinogenesis and
immunosuppression (Project 1); regulation of apoptosis in skin cancer
development (Project 2); DNA repair and chromosome instability in skin
cancers (Project 3); and adjuvant biotherapy of aggressive skin cancers
with 13-cis retinoic acid and interferon-alpha (Project 5). These studies
will be coordinated and supported by cores devoted to collection of
clinical, pathological, molecular, and epidemiological data and
procurement, maintenance, processing, and distribution of clinical samples
and biostatistical analysis and integration of laboratory and clinical
data. These efforts will be supported by 16 collaborators/co-investigators
and 8 Program Advisors. The Program Project will provide information on
the etiology, biology, pathogenesis, and mechanisms of induction of NMSC
and generate valuable clinical and epidemiological databases.
非黑色素瘤皮肤癌(NMSC)的发病率正在迅速增加
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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MARGARET L KRIPKE其他文献
MARGARET L KRIPKE的其他文献
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{{ truncateString('MARGARET L KRIPKE', 18)}}的其他基金
54th Annual Syposium on Fundamental Cancer Research
第 54 届基础癌症研究年度研讨会
- 批准号:
6368844 - 财政年份:2001
- 资助金额:
$ 83.57万 - 项目类别:
ROLE OF P53 IN UV IMMUNE SUPPRESSION AND CARCINOGENESIS
P53 在紫外线免疫抑制和致癌作用中的作用
- 批准号:
6643605 - 财政年份:2001
- 资助金额:
$ 83.57万 - 项目类别:
ROLE OF P53 IN UV IMMUNE SUPPRESSION AND CARCINOGENESIS
P53 在紫外线免疫抑制和致癌作用中的作用
- 批准号:
6485989 - 财政年份:2001
- 资助金额:
$ 83.57万 - 项目类别:
ROLE OF P53 IN UV IMMUNE SUPPRESSION AND CARCINOGENESIS
P53 在紫外线免疫抑制和致癌作用中的作用
- 批准号:
6311539 - 财政年份:2000
- 资助金额:
$ 83.57万 - 项目类别:
53RD ANNUAL SYMPOSIUM ON FUNDAMENTAL CANCER RESEARCH
第 53 届基础癌症研究年度研讨会
- 批准号:
6191804 - 财政年份:2000
- 资助金额:
$ 83.57万 - 项目类别:
ROLE OF P53 IN UV IMMUNE SUPPRESSION AND CARCINOGENESIS
P53 在紫外线免疫抑制和致癌作用中的作用
- 批准号:
6203325 - 财政年份:1999
- 资助金额:
$ 83.57万 - 项目类别:
ROLE OF P53 IN UV IMMUNE SUPPRESSION AND CARCINOGENESIS
P53 在紫外线免疫抑制和致癌作用中的作用
- 批准号:
6103104 - 财政年份:1998
- 资助金额:
$ 83.57万 - 项目类别:
IMMUNOLOGIC CONTROL OF MELANOMA PULMONARY METASTASIS
黑色素瘤肺转移的免疫控制
- 批准号:
2011640 - 财政年份:1997
- 资助金额:
$ 83.57万 - 项目类别:
ROLE OF P53 IN UV IMMUNE SUPPRESSION AND CARCINOGENESIS
P53 在紫外线免疫抑制和致癌作用中的作用
- 批准号:
6237593 - 财政年份:1997
- 资助金额:
$ 83.57万 - 项目类别:
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