53RD ANNUAL SYMPOSIUM ON FUNDAMENTAL CANCER RESEARCH

本申请申请资金用于抵消参加由德克萨斯大学安德森癌症中心主办的第53届基础癌症研究年度研讨会“癌症的遗传机制”的演讲者的差旅费用。会议将于2000年11月14日至17日在德克萨斯州休斯顿的j·w·万豪酒店举行。这些年度专题讨论会的长期传统和目标是吸引优秀的教师和科学领袖及时解决与癌症相关的当前话题。受邀的演讲者不仅要展示他们最新的数据，而且要确定未来研究的领域和问题。教育的机会，特别是对学生，在整个会议的设计提供。每堂课均安排正式问答时间。此外，还安排了海报会议，在会上展示提供的海报摘要。特别强调的是鼓励学生和初级教师参与这些会议。在休息时间和预定的餐饮活动（海报室的午餐和招待会）中提供非正式讨论的时间。研讨会将集中讨论癌症的遗传机制。邀请的演讲者是本次研讨会会议主题的世界领导人。会议的主题将通过五个科学会议来发展：(1)多因子遗传模型，(2)遗传变异和癌症的机制，(3)突变表型和癌症：DNA修复过程和癌症易感性，(4)肿瘤中基因表达的机制和变异，以及(5)肿瘤发生中的细胞周期和信号通路。会议的主题将根据动物模型的最新发展和对肿瘤发生的遗传控制机制的理解，在各届会议上加以阐述。此外，Ernst W. Bertner纪念奖将颁发给St. Jude儿童医院的Charles J. Sherr医生。Sherr博士和他的实验室在细胞周期调控和肿瘤发生的基因鉴定和表征方面做出了重大贡献。威尔逊S.斯通纪念奖将颁发给一位杰出的年轻科学家，他在遗传学研究方面对癌症研究做出了重大贡献。

This application requests funds to offset the travel expenses of the speakers who will participate in the 53rd Annual Symposium on Fundamental Cancer Research, "Genetic Mechanisms in Cancer", sponsored by The University of Texas M. D. Anderson Cancer Center. The meeting will be held November 14-17, 2000 in Houston, Texas at the J. W. Marriott Hotel. A long-standing tradition and goal of these annual symposia is to attract a faculty of outstanding quality and scientific leaders to address a timely and current topic of interest and relevance to cancer. Invited speakers are asked not only to present their most recent data, but to identify areas and issues for future study. Educational opportunities, especially for students, are provided throughout the meeting by design. Time is scheduled for formal questions/answers during each session. Additionally, poster sessions are scheduled at which proffered poster abstracts are displayed. A special emphasis is made to encourage student and junior faculty participation in these sessions. Time for informal discussions is provided during breaks and scheduled food functions (lunches in the poster room and receptions). The symposium will focus on the genetic mechanisms in cancer. Speakers to be invited are among the world leaders in the session topics of this symposium. The theme of the meeting will be developed through five scientific sessions: (1) Multifactorial Genetic Models, (2) Mechanisms of Genetic Variation and Cancer, (3) Mutator Phenotypes and Cancer: DNA Repair Processes and Cancer Susceptibility, (4) Mechanisms and Variation of Gene Expression in Neoplasia, and (5) Cell Cycle and Signaling Pathways in Tumorigenesis. The Conference theme will be elaborated across sessions in accord with the recent development of animal models and an understanding of the mechanisms of genetic control in tumorigenesis. In addition, the Ernst W. Bertner Memorial Award will be presented to Dr. Charles J. Sherr of St. Jude Children's Hospital. Dr. Sherr and his laboratory have made major contributions in the identification and characterization of genes involved in cell cycle regulation and tumorigenesis. The Wilson S. Stone Memorial Award will be presented to an outstanding young scientist whose research in genetics has made significant contributions to cancer research.