EPIDEMIOLOGY OF MEDICAL AND OROPHARYNGEAL CONDITIONS

医疗和口咽疾病的流行病学

• 批准号: 6270305
• 负责人: MARGARET S TERPENNING
• 金额: $ 15.71万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-07-01 至 1999-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6270305
• 关键词: dental caries; disease /disorder proneness /risk; drug adverse effect; epidemiology; functional ability; human old age (65+); human subject; longitudinal human study; myocardial infarction; oral bacteria; oral health; oral pharyngeal; periodontium disorder; platelet aggregation; pneumonia; stroke; swallowing; tobacco abuse; xerostomias

The principal goal of this project will be to model the significance of changes in the salivary flora, xerostomia, oropharyngeal flora, swallowing defects, and salivary of oral defence defects as risk factors for adverse dental and medical outcomes. We anticipate defining the population and assembling data from a fairly diverse elderly population. The major focus will be on older male veterans who are receiving medical care through the Veterans Administration. Initial information to be gathered under each of the other projects will be available for epidemiologic correlation through this epidemiology project. The biostatistics core will assist this project in order to discover the risk factors which are associated with each of the various medical and dental adverse outcomes. The methods will include longitudinal study of patients who are retained over a period of 2 to 5 years, recruitment of appropriate patients, coordination of patient followup and transportation for each site, scheduling of appropriate dental and medical followup, and gathering of specific information on medical outcomes. The epidemiology project will survey incoming data, make changes if needed in the pattern of recruitment of patients, follow patients' outcome over the entire 5 year period, and assess the meaning of the overall data collection. The data will include: 1) each of the dental risk factors found by the swallowing disorders project 3) the microbiological factors found by the microbiological project, 4) the gastric colonization project and 5) salivary factors noted in the oral defences projects. Outcome data to be collected will include medical illness, aspiration pneumonia, endocarditis, malnutrition, other medical odontogenic illnesses or death. In summary, the epidemiology project will be responsible for the collection of dental and medical information over the entire 5 year period, and intersection with the microbiology section, the immunologic section and the swallowing disorders section.

该项目的主要目标是模拟 唾液植物群、口干、口咽植物群、吞咽的变化 缺陷和唾液的口腔防御缺陷作为不良反应的危险因素 牙科和医疗结果。 我们预计将定义人口， 收集来自不同老年人群的数据。 主要重点 将针对通过医疗机构接受医疗护理的老年男性退伍军人 退伍军人管理局。 根据以下各项收集的初步资料： 其他项目将可用于流行病学相关性， 这个流行病学项目 生物统计学核心将协助这一项目 为了发现与每一种疾病相关的风险因素， 各种医疗和牙科不良后果。 方法包括 对保留2至5年的患者进行的纵向研究 年，招募适当的患者，协调患者 每个研究中心的随访和运输，安排适当的牙科 和医疗后续行动，并收集医疗方面的具体信息， 结果。 流行病学项目将调查输入的数据，做出改变 如果在患者招募模式中需要，遵循患者的 在整个5年期间的结果，并评估的意义， 整体数据收集。 数据将包括：1）每个牙科 吞咽障碍项目发现的危险因素3） 微生物项目发现的微生物因素，4） 胃定植项目和5）口腔中观察到的唾液因子 防御项目。 收集的结局数据将包括医学 疾病、吸入性肺炎、心内膜炎、营养不良、其他医疗 牙源性疾病或死亡 总之，流行病学项目将 负责收集牙科和医疗信息， 整个5年的时间，以及与微生物学部分的交叉， 免疫学部分和吞咽障碍部分。