EPIDEMIOLOGY OF MEDICAL AND OROPHARYNGEAL CONDITIONS

医疗和口咽疾病的流行病学

• 批准号: 6238439
• 负责人: MARGARET S TERPENNING
• 金额: $ 15.29万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-07-01 至 1998-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6238439
• 关键词: dental caries; disease /disorder proneness /risk; drug adverse effect; epidemiology; functional ability; human old age (65+); human subject; longitudinal human study; myocardial infarction; oral bacteria; oral health; oral pharyngeal; periodontium disorder; platelet aggregation; pneumonia; stroke; swallowing; tobacco abuse; xerostomias

The principal goal of this project will be to model the significance of changes in the salivary flora, xerostomia, oropharyngeal flora, swallowing defects, and salivary of oral defence defects as risk factors for adverse dental and medical outcomes. We anticipate defining the population and assembling data from a fairly diverse elderly population. The major focus will be on older male veterans who are receiving medical care through the Veterans Administration. Initial information to be gathered under each of the other projects will be available for epidemiologic correlation through this epidemiology project. The biostatistics core will assist this project in order to discover the risk factors which are associated with each of the various medical and dental adverse outcomes. The methods will include longitudinal study of patients who are retained over a period of 2 to 5 years, recruitment of appropriate patients, coordination of patient followup and transportation for each site, scheduling of appropriate dental and medical followup, and gathering of specific information on medical outcomes. The epidemiology project will survey incoming data, make changes if needed in the pattern of recruitment of patients, follow patients' outcome over the entire 5 year period, and assess the meaning of the overall data collection. The data will include: 1) each of the dental risk factors found by the swallowing disorders project 3) the microbiological factors found by the microbiological project, 4) the gastric colonization project and 5) salivary factors noted in the oral defences projects. Outcome data to be collected will include medical illness, aspiration pneumonia, endocarditis, malnutrition, other medical odontogenic illnesses or death. In summary, the epidemiology project will be responsible for the collection of dental and medical information over the entire 5 year period, and intersection with the microbiology section, the immunologic section and the swallowing disorders section.

该项目的主要目标将是模拟 唾液菌群的变化，口干，口咽菌群，吞咽 口腔防御缺陷和唾液缺陷是不良反应的危险因素 牙科和医疗结果。我们预计将定义人口和 从相当多样化的老年人口中收集数据。主要关注点 将针对正在通过 退伍军人管理局。在以下每个项目下收集的初始信息 其他项目将通过以下途径进行流行病学关联 这个流行病学项目。生物统计核心将协助这一项目 为了找出与每一个 各种医疗和牙科不良后果。这些方法将包括 留置2~5年以上患者的纵向研究 几年，招募合适的病人，协调病人 跟踪和运送每个地点，安排合适的牙科 和医疗跟踪，并收集关于医疗的特定信息 结果。流行病学项目将调查传入的数据，做出改变 如果在招募病人的模式中需要，遵循病人的 在整个5年期间的结果，并评估 整体数据收集。数据将包括：1)每个牙齿 吞咽障碍项目发现的风险因素3) 微生物项目发现的微生物因素，4) 胃定植计划和口腔中记录的唾液因素 防御项目。将收集的结果数据将包括医疗数据 疾病，吸入性肺炎，心内膜炎，营养不良，其他医学 牙源性疾病或死亡。总而言之，流行病学项目将 负责收集牙科和医疗方面的信息 整个5年的时间，并与微生物学部分交叉， 免疫科和吞咽障碍科。