Utilizing gametocyte immunity to reduce malaria transmission

利用配子体免疫减少疟疾传播

• 批准号: MR/T016272/1
• 负责人: Matthias Marti
• 金额: $ 278.2万
• 依托单位: University of Glasgow
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2020
• 资助国家: 英国
• 起止时间: 2020 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=MR%2FT016272%2F1
• 关键词: Utilizing; gametocyte; immunity; reduce; malaria

The continuing success of the current malaria elimination campaign requires novel tools to efficiently block human infection and subsequent transmission of the parasite to mosquitoes. Current transmission blocking strategies target the development of the parasite in the mosquito stage, requiring complicated mosquito feeding readouts to measure efficacy. We recently identified the bone marrow as the major site of transmission stage development during infection. Based on this finding we hypothesized that the underlying host parasite interactions could be exploited to block parasite transmission. Indeed our preliminary studies demonstrate natural immune responses against parasite surface antigens and their functionality in terms of immune clearance. Here we utilize this new understanding to systematically define the immunity targeting malaria transmission with the ultimate goal of prioritizing a set of novel transmission blocking vaccine candidates.

当前消除疟疾运动的持续成功需要新的工具来有效地阻止人类感染和随后的寄生虫传播给蚊子。目前的传播阻断策略针对的是蚊子阶段寄生虫的发育，需要复杂的蚊子摄食数据来衡量效果。我们最近发现骨髓是感染期间传播阶段发展的主要部位。基于这一发现，我们假设潜在的宿主与寄生虫的相互作用可以被利用来阻止寄生虫的传播。事实上，我们的初步研究证明了对寄生虫表面抗原的自然免疫反应及其在免疫清除方面的功能。在这里，我们利用这一新认识系统地定义针对疟疾传播的免疫，最终目标是优先考虑一套新的传播阻断疫苗候选。

项目成果

The acquisition of humoral immune responses targeting Plasmodium falciparum sexual stages in controlled human malaria infections.

• DOI: 10.3389/fimmu.2022.930956
• 发表时间: 2022
• 期刊: FRONTIERS IN IMMUNOLOGY
• 影响因子: 7.3
• 作者: de Jong, Roos M.;Alkema, Manon;Oulton, Tate;Dumont, Elin;Teelen, Karina;Nakajima, Rie;de Assis, Rafael Ramiro;Press, Kathleen W. Dantzler;Ngotho, Priscilla;Tetteh, Kevin K. A.;Felgner, Phil;Marti, Matthias;Collins, Katharine A.;Drakeley, Chris;Bousema, Teun;Stone, Will J. R.
• 通讯作者: Stone, Will J. R.

Plasmodium falciparum serology: A comparison of two protein production methods for analysis of antibody responses by protein microarray.

• DOI: 10.1371/journal.pone.0273106
• 发表时间: 2022
• 期刊: PLOS ONE
• 影响因子: 3.7
• 作者: Oulton, Tate;Obiero, Joshua;Rodriguez, Isabel;Ssewanyana, Isaac;Dabbs, Rebecca A.;Bachman, Christine M.;Greenhouse, Bryan;Drakeley, Chris;Felgner, Phil L.;Stone, Will;Tetteh, Kevin K. A.
• 通讯作者: Tetteh, Kevin K. A.