The Malaysian GestatiOnal Diabetes and prevention of DiabtES Study (MY GODDESS)

马来西亚妊娠期糖尿病和糖尿病预防研究（MY GODDESS）

• 批准号: MR/T018240/1
• 负责人: Khalida Ismail
• 金额: $ 48.01万
• 依托单位: King's College London
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2019
• 资助国家: 英国
• 起止时间: 2019 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=MR%2FT018240%2F1
• 关键词: Malaysian; GestatiOnal; Diabetes; prevention; DiabtES

Gestational diabetes is a condition that occurs during pregnancy when the blood sugar is higher than it should be. After the baby is born, the blood sugar returns to normal. The number of women in Malaysia that develop gestational diabetes is about 50,000 each year and these numbers are increasing with the worldwide epidemic of obesity. Around half od the women with gestational diabetes are likely to develop either type 2 diabetes or pre diabetes within 10 years. In other words, these women who are child-rearing and who may also be working outside the home, are developing diabetes in their 30s and 40s, almost 20 years before the average person. Gestational diabetes leads to further health problems and the baby can be born big-for-dates which increases his/her chances of developing type 2 diabetes later in life. Malays, Indian and Chinese Malaysians are all at high risk for getting diabetes.The chances of getting type 2 diabetes could be significantly reduced if women made lifestyle changes to lose weight and increase their physical activity. This can be very difficult with modern lifesyles and demands. Also getting gestational diabetes is usually a very upsetting experience because the mother feels guilty and also worrying about the health of her baby. There have been trials, mainly in North America, testing different types of lifestlyes but the findings from these trials are not clear cut. There have been no trials reported in Malaysia. We still do not know what kind of support women would find the most helpful.King's Health Partners has one of the largest clinical and research units for diabetes. We have been developing new approaches to supporting women with gestational diabetes (led by Prof Angus Forbes and Pro Helen Murphy). Our interviews with women with gestational diabetes showed that women in the UK have a poor understanding of their risk of developing diabetes and we think this might be the same for women in Malaysia. They also did not know how best to lower their risk and worried that exercise and different diet might harm their baby. We also found that women became very upset, guilty and burdened after they were told they had gestational diabetes. This project is called MY GODDESS and we aim to share the ideas and experiences of women in the UK and Malaysia. In the first set of studies, we will review the research already published and find out what works and what doesn't. We will focus on studies that uses digital technology such as apps, websites from the smartphone or computer. We will then interview women with a history of gestational diabetes and ask what was difficult about making lifestyle changes and what helped. We will then use use our shared knowledge as researchers and as patients to design a new treatment to support lifestyle change. We will consider ideas such as group sessions, lifestyle coaches text messages, and wearing devices that measure our step counts and heart rate. We will develop the MY GODDESS app which can be downloaded onto a smartphone. We believe that if we understand better how to harness the 'health power' in digital technology, we will produce stronger support systems to help women with GDM lead healthier lifestyles. The second project is to test our new treatment, MY GODDESS, in a small study to see if we could test our new could be conducted at a largerthat it does help women to make lifestyle changes. We will recruit about 50 patients. We will study how many women we could identify, who will be interested in participating and who will stay in the treatment to the end. We will ask women for feedback about their experience, what worked and what did not and any suggestions about improvement.By the end of the project if our findings are in the right direction, we will submit a proposal to conduct a full scale trial to test whether MY GODDESS works in a much larger sample of women across Malaysia.

妊娠期糖尿病是一种发生在怀孕期间血糖高于正常水平的疾病。婴儿出生后，血糖恢复正常。马来西亚每年约有5万名妇女患妊娠期糖尿病，随着全球肥胖症的流行，这一数字还在增加。大约一半患有妊娠期糖尿病的妇女可能在10年内发展为2型糖尿病或糖尿病前期。换句话说，这些既要抚养孩子又要在外工作的女性，在三四十岁时患上糖尿病，比一般人早了将近20年。妊娠糖尿病会导致进一步的健康问题，婴儿可能会提前出生，这增加了他/她在以后的生活中患2型糖尿病的机会。马来人、印度人和马来西亚华人都是患糖尿病的高危人群。如果女性改变生活方式，减轻体重，增加体育锻炼，患2型糖尿病的几率就会大大降低。在现代的生活方式和需求下，这是非常困难的。此外，患妊娠糖尿病通常是一种非常令人沮丧的经历，因为母亲感到内疚，也担心孩子的健康。有一些试验，主要是在北美，测试了不同类型的生活方式，但这些试验的结果并不明确。马来西亚还没有审判的报道。我们仍然不知道什么样的支持对女性最有帮助。King's Health Partners拥有最大的糖尿病临床和研究单位之一。我们一直在开发新的方法来支持患有妊娠糖尿病的妇女（由安格斯·福布斯教授和海伦·墨菲教授领导）。我们对患有妊娠糖尿病的女性的采访表明，英国女性对患糖尿病的风险了解不足，我们认为马来西亚女性可能也是如此。她们也不知道如何最好地降低风险，担心运动和不同的饮食可能会伤害她们的孩子。我们还发现，女性在被告知自己患有妊娠糖尿病后，会变得非常沮丧、内疚和负担沉重。这个项目被称为MY GODDESS，我们的目标是分享英国和马来西亚女性的想法和经验。在第一组研究中，我们将回顾已经发表的研究，找出哪些有效，哪些无效。我们将专注于使用数字技术的研究，如智能手机或电脑上的应用程序、网站。然后，我们将采访有妊娠糖尿病史的女性，询问改变生活方式的困难是什么，以及有什么帮助。然后，我们将利用我们作为研究人员和患者的共同知识来设计一种新的治疗方法来支持生活方式的改变。我们会考虑小组会议、生活方式教练短信、佩戴测量步数和心率的设备等想法。我们将开发可以下载到智能手机上的“我的女神”应用程序。我们相信，如果我们更好地了解如何利用数字技术中的“健康力量”，我们将建立更强大的支持系统，帮助患有GDM的妇女过上更健康的生活方式。第二个项目是测试我们的新疗法，我的女神，在一个小的研究中，看看我们是否可以测试我们的新疗法是否可以在更大的范围内进行，它确实可以帮助女性改变生活方式。我们将招募大约50名患者。我们将研究我们能确定多少女性，哪些人有兴趣参与，哪些人会坚持到最后。我们将要求女性反馈她们的经历，什么有用，什么没用，以及任何改进的建议。在项目结束时，如果我们的发现是正确的，我们将提交一份建议，进行全面的试验，以测试MY GODDESS是否在马来西亚更大的女性样本中有效。

项目成果

Study protocol on risk factors for the diagnosis of gestational diabetes mellitus in different trimesters and their relation to maternal and neonatal outcomes (GDM-RIDMAN).

• DOI: 10.1136/bmjopen-2021-052554
• 发表时间: 2022-07-26
• 期刊: BMJ OPEN
• 影响因子: 2.9
• 作者: Yap, Pamela Phui Har;Nadal, Iliatha Papachristou;Rysinova, Veronika;Basri, Nurul Iftida;Samsudin, Intan Nureslyna;Forbes, Angus;Noor, Nurain Mohd;Supian, Ziti Akthar;Hassan, Haslinda;Paimin, Fuziah;Zakaria, Rozita;Alias, Siti Rohani Mohamed;Bukhary, Norizzati Bukhary Ismail;Benton, Madeleine;Ismail, Khalida;Chew, Boon How
• 通讯作者: Chew, Boon How

A Mobile Phone App for the Prevention of Type 2 Diabetes in Malaysian Women With Gestational Diabetes Mellitus: Protocol for a Feasibility Randomized Controlled Trial.

用于预防马来西亚妊娠糖尿病女性 2 型糖尿病的手机应用程序：可行性随机对照试验方案。

• DOI: 10.2196/37288
• 发表时间: 2022-09-08
• 期刊: JMIR RESEARCH PROTOCOLS
• 影响因子: 1.7
• 作者: Benton, Madeleine;Iman, Iklil;Goldsmith, Kimberley;Forbes, Angus;Ching, Siew Mooi;Nadal, Iliatha Papachristou;Guess, Nicola;Murphy, Helen R.;Yusof, Barakatun-Nisak Mohd;Baharom, Anisah;Sobri, Nur Hafizah Mahamad;Basri, Nurul Iftida;Salim, Mazatulfazura Sf;Ismail, Irmi Zarina;Hassan, Faezah;Ismail, Khalida;Chew, Boon How
• 通讯作者: Chew, Boon How

Protocol for a qualitative study exploring the perception of need, importance and acceptability of a digital diabetes prevention intervention for women with gestational diabetes mellitus during and after pregnancy in Malaysia (Explore-MYGODDESS).

• DOI: 10.1136/bmjopen-2020-044878
• 发表时间: 2021-08-26
• 期刊: BMJ open
• 影响因子: 2.9
• 作者: Sobri NHM;Ismail IZ;Hassan F;Papachristou Nadal I;Forbes A;Ching SM;Ali H;Goldsmith K;Murphy H;Guess N;Mohd Yusof BN;Basri NI;Salim MS;Azmiyaty C;Mohd Sa'id II;Chew BH;Ismail K;MYGODDESS Project Team
• 通讯作者: MYGODDESS Project Team

Systematic review and meta-analysis of risk of gestational diabetes in women with preconception mental disorders.

患有孕前精神障碍的女性妊娠期糖尿病风险的系统回顾和荟萃分析。

• DOI: 10.1016/j.jpsychires.2022.03.013
• 发表时间: 2022
• 期刊: Journal of psychiatric research
• 影响因子: 4.8
• 作者: Wilson CA

Development of type 2 diabetes in women with comorbid gestational diabetes and common mental disorders in the Born in Bradford cohort.

患有妊娠糖尿病的妇女的2型糖尿病的发育和布拉德福德同龄人的常见精神障碍的发展。

• DOI: 10.1136/bmjopen-2021-051498
• 发表时间: 2022-03-14
• 期刊: BMJ open
• 影响因子: 2.9
• 作者: Wilson CA;Santorelli G;Reynolds RM;Simonoff E;Howard LM;Ismail K
• 通讯作者: Ismail K