STATISTICAL MODELS IN TOXICOLOGY AND BIOCHEMISTRY

毒理学和生物化学的统计模型

• 批准号: 6106665
• 负责人: Christopher J Portier
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6106665
• 关键词: biochemistry; cancer risk; cell cycle; chemical carcinogen; chemical carcinogenesis; dioxins; environmental toxicology; female; laboratory rat; liver neoplasms; mathematical model; model design /development; mutagens; preneoplastic state; statistics /biometry; thyroid hormones

Summary of Work: This project is intended to increase our understanding of the use and application of mathematical and statistical models in toxicology and biochemistry and to implement these mathematical models to aid in explaining current research findings. The research effort explores a diverse range of biological areas, including carcinogenesis, pharmacology, developmental biology, neurology, immunology and endocrinology. Major accomplishments include (1) evaluation of the risks from exposure to pwer-line frequency electric and magnetic fields (2) the derivation of methods for the analysis of carcinogenicity data including data on papillomas, carcinomas and maintaining tissue size (3) new stochastic models of carcinogenesis (4) methods were developed for linking PBPK models, premalignant lesion data, cell labelling data and tumor incidence data (5) models for mortality/morbidity in urban areas are being validated in a Japanese population (6) exposure assessment models have been developed (7) built and experimentally validated a mathematical model describing the specific phases of the cell cycle (8) developed methods for evaluating the adequacy of benchmark doses, (9) developed a toxicodynamic model of the rat estrus cycle, and (10) continued to aid in the scientific improvement of risk assessment methods through the application of sound science to key environmental issues such as exposure to TCDD, aflatoxins and endocrine disruptors.

工作总结：该项目旨在 增加我们对使用和应用的了解 毒理学和生物化学中的数学和统计模型 并实施这些数学模型来帮助解释 目前的研究成果。这项研究努力探索了一种不同的 生物学领域，包括致癌、药理学、 发育生物学、神经学、免疫学和内分泌学。 主要成就包括(1)评估来自 暴露在工频电场和磁场中(2) 致癌性数据分析方法的推导 包括乳头状瘤、癌和维持性组织的数据 大小(3)新的致癌随机模型(4)方法 开发用于连接PBPK模型、癌前病变数据、细胞 标签数据和肿瘤发病率数据(5)模型 城市地区的死亡率/发病率正在日本的一项研究中得到验证 已开发了人口(6)暴露评估模型 (7)建立了数学模型并进行了实验验证 描述细胞周期的特定阶段(8) 评价基准剂量充分性的方法，(9) 建立了大鼠发情周期的毒理动力学模型，以及(10) 继续协助提高风险评估的科学性 方法通过将声音科学应用于关键字 环境问题，如接触TCDD、黄曲霉毒素和 内分泌干扰物。