STATISTICAL MODELS IN TOXICOLOGY AND BIOCHEMISTRY

工作总结：本项目旨在 提高我们对使用和应用的理解 毒理学和生物化学中的数学和统计模型 并利用这些数学模型来帮助解释 目前的研究成果。研究工作探索了一个多样化的 一系列生物学领域，包括致癌作用，药理学， 发育生物学、神经学、免疫学和内分泌学。 主要成果包括：（1）评估风险， 暴露于工频电场和磁场（2）， 致癌性数据分析方法的推导 包括乳头状瘤、癌和维持组织 规模（3）新的随机模型的致癌作用（4）方法， 开发用于将PBPK模型、癌前病变数据、细胞 标签数据和肿瘤发病率数据（5） 城市地区的死亡率/发病率正在日本 人口（6）暴露评估模型已经开发 (7)建立并实验验证了数学模型 描述细胞周期的特定阶段（8） 评价基准剂量适当性的方法，（9） 开发了大鼠发情周期的毒理学模型，以及（10） 继续协助科学改进风险评估 方法通过应用健全的科学，以关键 环境问题，如接触TCDD、黄曲霉毒素和 内分泌干扰物

Summary of Work: This project is intended to increase our understanding of the use and application of mathematical and statistical models in toxicology and biochemistry and to implement these mathematical models to aid in explaining current research findings. The research effort explores a diverse range of biological areas, including carcinogenesis, pharmacology, developmental biology, neurology, immunology and endocrinology. Major accomplishments include (1) evaluation of the risks from exposure to pwer-line frequency electric and magnetic fields (2) the derivation of methods for the analysis of carcinogenicity data including data on papillomas, carcinomas and maintaining tissue size (3) new stochastic models of carcinogenesis (4) methods were developed for linking PBPK models, premalignant lesion data, cell labelling data and tumor incidence data (5) models for mortality/morbidity in urban areas are being validated in a Japanese population (6) exposure assessment models have been developed (7) built and experimentally validated a mathematical model describing the specific phases of the cell cycle (8) developed methods for evaluating the adequacy of benchmark doses, (9) developed a toxicodynamic model of the rat estrus cycle, and (10) continued to aid in the scientific improvement of risk assessment methods through the application of sound science to key environmental issues such as exposure to TCDD, aflatoxins and endocrine disruptors.