CORE--ANALYTIC CORE

核心分析实验室负责定量 广泛的调解人，可能被证明是至关重要的， 肺功能障碍的发展。 核心实验室提供以下方面的专业知识 所有形式的色谱法，定量质谱法， 放射免疫分析和ELISA。 每个项目生成的样本将 运输到核心实验室进行储存和后续分析， 以便最佳利用人员和减少用品费用。 建议的测定包括用于脂质介质（TxB 2，6-酮基- PGF 1 α、PGE 2、花生四烯酸、LTB和TxB 2的尿代谢物， 和前列环素），细胞因子（TNF，IL-1，IL-6和IL-8）， 内皮素、谷胱甘肽和报告基因测定（氯霉素 乙酰转移酶）。 该核心实验室将处理5000多个样本， 一年，促使与SCOR调查人员的互动， 并强调需要持续的质量保证。

The Core Analytical Laboratory has responsibility for quantification of a broad range of mediators that may prove to be pivotally important in the development of lung dysfunction. The Core Lab provides expertise in all forms of chromatography, quantitative mass spectrometry, radioimmunoassay and ELISA. Samples generated by each project will be transported to the Core Lab for storage and subsequent analysis, allowing for optimal use of personnel and a reduction in cost of supplies. Proposed assays include those for lipid mediators (TxB2, 6-keto- PGF1alpha, PGE2, arachidonic acid, LTB, and urinary metabolites of TxB2, and prostacyclin), cytokines (TNF, IL-1, IL-6 and IL-8), endothelin,glutathione, and reporter gene assays (chloramphenicol acetyltransferase). This Core Lab will process over 5000 samples per year, prompting interaction with the SCOR investigators on an almost daily basis and underscoring the need for ongoing quality assurance.