CELLULAR ACTIVATION IN PPH--ENDOGENOUS AND EXOGENOUS PROSTACYCLIN

本研究旨在探讨其生理生化机制。 慢性阻塞性肺疾病患者输注氟罗兰引起的快速便秘 通过检查高血压患者输液速度与血压的关系 氟罗兰和一种可测量的血浆代谢物6-酮-前列腺素F1a在 初始剂量以及在长期给药期间。这项研究将 也要调查与“戒烟综合症”相关的变化 当输液突然中断时会发生这种情况，并评估其效果 急、慢性氟兰输注对体内血小板活化的影响。 我们目前正在计算一些正常志愿者的数据， 继续招收PPH患者。

This study is to determine the physiological and biochemical mechanisms of tachyphlaxis to infused Flolan in patients with Primary Pulmonalry Hypertension by examining the relationship between the rate of infusion of Flolan and a measurable plasma metabolite, 6-keto-PGF1a, during the initial dosing as well as during chronic administration. This study will also investigate the changes associated with the "cessation Syndrome" that occurs when infusion is abruptly interrupted and evaluate the effect acute and chronic Flolan infusion on in vivo platelet activation. We are currently calculating data from some of our normal volunteers and continue to enroll PPH patients.