CENTER FOR RESEARCH ON FERTILITY AND INFERTILITY

这份P30中心核心助学金续签申请是 过去15年通过以下方式发展起来的研究需求 西北大学从事生殖研究的研究人员 在生育和不育领域的研究。十四 调查人员目前持有25项国家卫生研究院资助的研究资助/项目 将访问四个拟议的科学核心。其中的16个 赠款/项目由NICHD提供资金。研究计划将是 由P30中心核心赠款提供的服务包括对 生殖神经内分泌学--性腺的调节机制 功能，配子发生的调节机制，以及 卵泡选择，生殖激素的作用机制， 涉及生殖的基因的转录调控， 生殖道功能的调节机制与免疫学 调节生育的机制。拟议中的P30中心的调查人员 Core Grant目前正在解决生殖科学中的问题 在生化、分子、细胞、生理和行为方面 级别。生命科学在生殖领域的复杂性 今天的研究需要共享技术和方法，这些技术和方法 通常在单一的研究实验室中无法获得。事实上，很明显 在我们对生殖系统的理解上的重大突破 将需要具有以下专业知识的研究人员的合作努力 不同的研究领域。因此，这笔赠款旨在维持三个 已建立的核心(蛋白质分析、原位杂交/分子 技术，以及激素和神经递质测量核心)，以及 创建一个新的核心(重组蛋白核心)，这将使核心 调查人员将高度尖端的技术融入他们的 以具有成本效益的方式开展研究计划。此外，这些核心将 在多个不同领域提供质量控制和技术专长 个人通常无法使用的方法 调查人员。还将继续设立一个行政核心 管理中心助学金。P30中心核心的建立 四年前的授予已经对质量、数量和 美国联邦政府资助的现有研究项目的成本效益 西北大学生殖科学专业。它还培育了 P30中心成员之间的广泛合作以及 P30调查人员和其他科学家之间的合作 西北大学。续期中包括的现有核心和新核心 P30核心中心资助金之所以被选中，是因为他们的影响力很大 有望在西北大学进行生殖研究，即 旨在更好地了解监管机制 潜在的生育和不孕。

This P30 Center Core Grant renewal application is a direct outgrowth of the research needs that have developed over the past 15 years by investigators at Northwestern University who are engaged in reproductive research in the areas of fertility and infertility. Fourteen investigators currently holding 25 funded NIH research grants/projects will access the four proposed scientific cores. Sixteen of these grants/projects are funded through the NICHD. The research programs to be served by the P30 Center Core Grant include investigations into the neuroendocrinology of reproduction, the regulatory mechanisms of gonadal functions, the regulatory mechanisms of gametogenesis, the mechanisms of follicular selection, the mechanisms of action of reproductive hormones, the transcriptional regulation of genes involved in reproduction, the mechanisms regulating genital track functions and the immunological mechanisms regulating fertility. Investigators in the proposed P30 Center Core Grant are currently addressing questions in the reproductive sciences at the biochemical, molecular, cellular, physiological and behavioral levels. The complexity of the life sciences in the area of reproductive research today requires the sharing of techniques and approaches that are often not available in a single research laboratory. Indeed, it is clear that major breakthroughs in our understanding of the reproductive system will require collaborative efforts of researchers who have expertise in diverse areas of research. Thus, this grant seeks to maintain three established cores (Protein Analysis, In Situ Hybridization/Molecular Technology, and Hormone and Neurotransmitter Measurement Cores), and to create one new core (Recombinant Protein Core) which will enable Core investigators to incorporate highly sophisticated techniques into their research programs in a cost-effective manner. Furthermore, the Cores will provide quality control and technical expertise in a number of different methodologies at a level normally not available to individual investigators. An Administrative Core will also be continued to administer the Center Grant. The establishment of this P30 Center Core Grant four years ago has had a major impact on the quality, quantity and cost-effectiveness of existing federally-funded research programs in the reproductive sciences at Northwestern University. It has also fostered extensive collaborations between members of the P30 Center as well as between P30 investigators and other scientists both within and outside of Northwestern. The established and new cores included in the renewal of the P30 Core Center Grant were selected because of the high impact they can be expected to have on reproductive research at Northwestern that is aimed at developing a better understanding of the regulatory mechanisms underlying fertility and infertility.