PURCHASE OF A GAS CHROMOTOGRAPH MASS SPECTROMETER

该提案要求为气相色谱仪-质谱仪提供资金 分光计。扩大新闻部的用户群体 加州大学欧文分校化学专业通过招聘 高级和初级教员以及研究项目的发展 其中对两个增加的样本都有特定的要求 容量和实时回答证明了对此的迫切需求 用于获取无法获得的重要分析数据的仪器 通过其他技术。UCI的质谱学设施包括 两个磁扇区的仪器是完全饱和的， 为合成程序提供分析支持(精确质量测定)和 其他问题的解决，特别是使用LSIMS、直接探头和FD。 主要用户的研究项目包括：(A)Shea，(B)Overman- 新反应和新策略的发现及配合物的合成 分子，特别是通过多个立体专一性的环形成， (C)Rychnovsky-结构测定和收敛合成 多烯大环内酯类抗生素，手性氮氧化物作为对映体选择性 氧化催化剂；(D)范弗拉肯-脱芳构化反应 通过芳香族[2，3]-Wit反应研究的化学体系 和不对称版本的Sommelet-Hauser和Thia-Sommelet 使用2，6-二取代芳烃的反应；(E)沃尔佩尔立体专一性 尤其是涉及插入硅环丙烷的合成， α-烷氧基烯丙基硅烷的重排，锂的烯醇化学 和钯催化的偶联反应。除了主要用户之外 可能还有其他NIH资助的研究小组紧急 需要GC-MS功能。仪器将配备用于EI。 和CI，这两个都是获得结构性 信息。此外，通过使用自动取样器和适当的 计算能力仪器将针对有限数量进行格式化 的研究生用户，因此将能够提供 将乐器放在下方时需要的回转类型 经验丰富的质谱学家的控制，设施主任 有20多年的经验，其中大部分是利用GC-MS。UCI有一个 对质谱学设施的长期重大资金承诺为 以及其他分析光谱分析仪器设备 为研究人员提供支持。目前每年的承诺是 近500,000美元用于这些设施的工资和运营 支持。通过收取以下费用获得额外的运营资金 用户社区的授权和合同。

This proposal requests funding for a gas chromatograph-mass spectrometer. Expansion of the user community in the Department of Chemistry at the University of California, Irvine, through recruitment of senior and junior faculty and a the development of research projects in which there are specific requirements for both increased sample capacity and real-time answers demonstrate the urgent need for this instrumentation to obtain vital analytical data that cannot be obtained by other techniques. The UCI mass spectrometry facility which comprises of two magnetic sector instruments is fully saturated providing analytical support for synthetic program (exact mass determinations) and other problem solving, particularly using LSIMS, direct probe and FD. Research projects of the major users include: (a) SHEA, (b) Overman- discovery of new reactions and strategies and the synthesis of complex molecules, particularly through multiple stereospecific ring formation, (c) Rychnovsky- structure determination and convergent synthesis of polyene macrolide antibiotics, chiral nitroxides as enantioselective oxidation catalysts; (d) Van Vranken-dearomatization reactions in chemical systems investigated via the aromatic [2,3]-Witting reaction and asymmetric versions of the Sommelet-Hauser and thia-Sommelet reaction using 2,6-disubstituted aromatics; (e) Woerpel-stereospecific synthesis particularly involving insertions into silacyclopropanes, rearrangements of alpha-alkoxyallylsilanes, lithium enolate chemistry and palladium catalyzed coupling reactions. Aside from the major user group there are may other NIH funded research groups who urgently require GC-MS capability. The instrumentation is to be equipped for EI and CI, both of which are essential for obtaining structural information. In addition, by using an autosampler and appropriate computing capacity the instrument will be formatted for a limited number of graduate student users and will, therefore, be able to provide the type of turn around that is needed while leaving the instrument under the control of experienced mass spectroscopists, the facility director has over 20 years experience much of it utilizing GC-MS. UCI has a long-term major funding commitment to the mass spectrometry facility as well as the other analytical spectroscopy instrumentation facilities which support the research faculty. Currently the annual commitment is almost 500,000 dollars to these facilities in salaries and operational support. Additional operational funding is obtained though charges to the grants and contracts of the user community.