PURCHASE OF A GAS CHROMOTOGRAPH MASS SPECTROMETER

购买气相色谱质谱仪

• 批准号: 2503088
• 负责人: KENNETH J SHEA
• 金额: $ 14.73万
• 依托单位: UNIVERSITY OF CALIFORNIA-IRVINE
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-05-15 至 1999-11-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2503088
• 关键词: biomedical equipment; biomedical equipment purchase; gas chromatography mass spectrometry

This proposal requests funding for a gas chromatograph-mass spectrometer. Expansion of the user community in the Department of Chemistry at the University of California, Irvine, through recruitment of senior and junior faculty and a the development of research projects in which there are specific requirements for both increased sample capacity and real-time answers demonstrate the urgent need for this instrumentation to obtain vital analytical data that cannot be obtained by other techniques. The UCI mass spectrometry facility which comprises of two magnetic sector instruments is fully saturated providing analytical support for synthetic program (exact mass determinations) and other problem solving, particularly using LSIMS, direct probe and FD. Research projects of the major users include: (a) SHEA, (b) Overman- discovery of new reactions and strategies and the synthesis of complex molecules, particularly through multiple stereospecific ring formation, (c) Rychnovsky- structure determination and convergent synthesis of polyene macrolide antibiotics, chiral nitroxides as enantioselective oxidation catalysts; (d) Van Vranken-dearomatization reactions in chemical systems investigated via the aromatic [2,3]-Witting reaction and asymmetric versions of the Sommelet-Hauser and thia-Sommelet reaction using 2,6-disubstituted aromatics; (e) Woerpel-stereospecific synthesis particularly involving insertions into silacyclopropanes, rearrangements of alpha-alkoxyallylsilanes, lithium enolate chemistry and palladium catalyzed coupling reactions. Aside from the major user group there are may other NIH funded research groups who urgently require GC-MS capability. The instrumentation is to be equipped for EI and CI, both of which are essential for obtaining structural information. In addition, by using an autosampler and appropriate computing capacity the instrument will be formatted for a limited number of graduate student users and will, therefore, be able to provide the type of turn around that is needed while leaving the instrument under the control of experienced mass spectroscopists, the facility director has over 20 years experience much of it utilizing GC-MS. UCI has a long-term major funding commitment to the mass spectrometry facility as well as the other analytical spectroscopy instrumentation facilities which support the research faculty. Currently the annual commitment is almost 500,000 dollars to these facilities in salaries and operational support. Additional operational funding is obtained though charges to the grants and contracts of the user community.

该提案要求资助气相色谱质量 光谱仪。 扩大部门的用户社区 加州大学欧文分校化学系，通过招聘 高级和初级教师以及研究项目的开发 其中对于增加的样本都有特定的要求 容量和实时答案表明了对此的迫切需求 仪器以获得无法获得的重要分析数据 通过其他技术。 UCI 质谱设施包括 两个磁扇区仪器完全饱和，提供 合成程序的分析支持（精确质量测定）和 其他问题解决，特别是使用 LSIMS、直接探针和 FD。 主要用户的研究项目包括：(a) SHEA，(b) Overman- 新反应和策略的发现以及复杂的合成 分子，特别是通过多个立体特异性环的形成， (c) Rychnovsky-结构确定和收敛合成 多烯大环内酯类抗生素、手性硝基氧作为对映选择性 氧化催化剂； (d) Van Vranken-脱芳构化反应 通过芳香族 [2,3]-Witting 反应研究化学系统 以及 Sommelet-Hauser 和 thia-Sommelet 的不对称版本 使用2,6-二取代芳族化合物的反应； (e) Woerpel-立体定向 合成特别涉及插入硅杂环丙烷， α-烷氧基烯丙基硅烷的重排，烯醇锂化学 和钯催化的偶联反应。 除了主要用户 小组可能还有其他 NIH 资助的研究小组，他们迫切需要 需要 GC-MS 功能。 EI需配备仪器 和 CI，两者对于获得结构都是必不可少的 信息。 此外，通过使用自动进样器和适当的 仪器的计算能力将被格式化为有限数量 研究生用户，因此将能够提供 将仪器放置在下面时所需的翻转类型 经验丰富的质谱学家、设施主任的控制 拥有 20 多年使用 GC-MS 的经验。 UCI 有一个 对质谱设施的长期主要资助承诺 以及其他分析光谱仪器设施 支持研究人员。 目前每年的承诺是 为这些设施提供近 50 万美元的工资和运营费用 支持。 通过收费获得额外的运营资金 用户社区的赠款和合同。