PURCHASE OF MICROCALORIMETRY EQUIPMENT

用于购买微量热仪设备的资金， 一个大型的NIH资助的研究人员在加州大学洛杉矶分校的研究被要求。 差示扫描量热仪和等温滴定法 将购买热量计，并放置在生化 仪器中心，以最大限度地提高其可用性的研究 加州大学洛杉矶分校的社区描述了四个主要用户的研究项目 具有以下标题：1）热力学和突变分析的 肌球蛋白跨桥循环中的强束缚态; 2）测量 二酰基甘油激酶变体的稳定性：一种模型膜蛋白; 3） 微量热法研究聚乙烯醇的热稳定性及其增溶作用 铜锌超氧化物歧化酶突变蛋白的金属离子不稳定性 TN 916整合酶的量热研究。

Funds for the purchase of microcalorimetry equipment to support the research of a large group of NIH-funded researchers at UCLA are requested. A differential scanning calorimeter and an isothermal titration calorimeter will be purchased and placed in the Biochemical Instrumentation Center to maximize its availability to the research community at UCLA. The research projects of four major users are described with the following titles: 1) Thermodynamic and Mutational Analysis of the Strongly Bound States in the Myosin Cross-Bridge Cycle; 2) Measuring the Stability of Diacylglycerol Kinase Variants: a Model Membrane Protein; 3) Microcalorimetric Studies on the Thermal Stability of and the Increased Metal Ion Lability of FALS-Mutant Proteins of Copper-Zinc Superoxide Dismutase; 4) Calorimetric Studies of TN916 Integrase.