MRC-1024 KRYPTON/ARGON IMAGING SYSTEM

一组由九名NIH资助的研究人员代表五个不同的 部门申请资金购买Bio-Rad MRC-1024 Confocal 显微镜系统将容纳在Vision内并由Vision管理 伯明翰亚拉巴马大学科学研究中心 （UAB）。第二组用户，他们的研究是由各种各样的资助， 来源，每个人将需要1%或更少的仪器使用， 也在申请中列出。 VSRC，其中包括40名科学家分布在11个 UAB校园的部门，最近被指定为UAB大学 广泛的跨学科研究中心。VSCRC管理了一个NIH 自1979年以来，资助核心赠款，因此，有十八年的时间， 在维护设施和提供服务方面的经验， UAB的研究社区。列出的研究者所属机构 这个应用程序包括心理学，细胞生物学， 生理光学，（视光学学院），眼科学和医学。 因此，所要求文书的主要用户代表了广泛的 是UAB生物医学研究界的第二大交叉点 进入CLSM设施是非常有限的UAB校园。唯一的 单位是一个八岁的萨拉斯特罗仪器位于该部 神经生物学这一工具在有限的基础上提供， 不适合本提案中描述的许多应用 由于它的年龄和技术限制， 单位配置了一个旧的显微镜，产生非常低的 光传输效率是否有一项文书，例如 Bio-Rad MRC-1024在UAB校园将有重大影响， 九名NIH资助的研究人员的研究项目被列为主要研究项目。 用户，并为更广泛的UAB生物医学提供了所需的资源 研究社区。

A group of nine NIH-funded investigators representing five different departments requests funds to purchase a Bio-Rad MRC-1024 Confocal Microscope System to be housed within, and administered by, the Vision Science Research Center (VSRC) of the University of Alabama at Birmingham (UAB). A second group of users, whose research is funded from a variety of sources and each of whom would require 1% or less of the instrument usage, are listed in the application as well. The VSRC, which includes forty scientists distributes among eleven departments on the UAB campus, was recently designated as a UAB University Wide Interdisciplinary Research Center. The VSCRC has administered an NIH funded CORE Grant since 1979 and, therefore, has eighteen years of experience in maintaining facilities for, and providing services to, the research community at UAB. The affiliations of the investigators listed on this application include the Departments of Psychology, Cell Biology, Physiological Optics, (School of Optometry), Ophthalmology, and Medicine. Thus, the primary users of the requested instrument represent a broad cross second of the biomedical research community at UAB. Access to CLSM facilities is extremely limited on the UAB campus. The only unit is a eight year old Sarastro instrument located in the Department of Neurobiology. This instrument, which is available on a restricted basis, is unsuitable for many of the applications described in this proposal because of its age and technical limitations including the fact that the unit is configured with an older microscope which yields a very low optical transfer efficiency. The availability of an instrument such as the Bio-Rad MRC-1024 on the UAB campus would have a major impact on the research programs of the nine NIH-funded investigators listed as primary users and provided a needed resourced for the broader UAB biomedical research community.