MRC-1024 KRYPTON/ARGON IMAGING SYSTEM

由美国国立卫生研究院资助的九名调查人员组成的小组，代表五个不同的 各部门申请资金购买Bio-Rad MRC-1024 Conocus 显微镜系统将安装在视觉系统内并由其管理 阿拉巴马大学伯明翰分校科学研究中心 (UAB)。第二组用户，他们的研究资金来自各种 并且每个源将需要1%或更少的仪器使用， 也列在应用程序中。 VSRC包括40名科学家，分布在11个 UAB校区的各系，最近被指定为UAB大学 广泛的跨学科研究中心。VSCRC已经对NIH进行了 自1979年以来由核心赠款供资，因此，有18年的 有维护设施和为其提供服务的经验 UAB的研究社区。上列出的调查人员的从属关系 这个应用包括心理学，细胞生物学， 生理光学(验光学院)、眼科和医学。 因此，所请求的文书的主要用户代表着广泛的 UAB生物医学研究社区的第二个十字勋章。 在UAB园区内，对CLSM设施的访问极其有限。唯一的 单位是一个有八年历史的萨拉斯特罗仪器，位于 神经生物学。这种仪器，在有限的基础上提供， 不适用于本建议书中描述的许多应用程序 因为它的年龄和技术限制，包括事实是 单元配置了较旧的显微镜，可产生非常低的 光学传输效率。一种工具的可用性，如 UAB园区的Bio-Rad MRC-1024将对 NIH资助的9名研究人员的研究计划被列为主要项目 并为更广泛的UAB生物医学提供了所需的资源 研究社区。

A group of nine NIH-funded investigators representing five different departments requests funds to purchase a Bio-Rad MRC-1024 Confocal Microscope System to be housed within, and administered by, the Vision Science Research Center (VSRC) of the University of Alabama at Birmingham (UAB). A second group of users, whose research is funded from a variety of sources and each of whom would require 1% or less of the instrument usage, are listed in the application as well. The VSRC, which includes forty scientists distributes among eleven departments on the UAB campus, was recently designated as a UAB University Wide Interdisciplinary Research Center. The VSCRC has administered an NIH funded CORE Grant since 1979 and, therefore, has eighteen years of experience in maintaining facilities for, and providing services to, the research community at UAB. The affiliations of the investigators listed on this application include the Departments of Psychology, Cell Biology, Physiological Optics, (School of Optometry), Ophthalmology, and Medicine. Thus, the primary users of the requested instrument represent a broad cross second of the biomedical research community at UAB. Access to CLSM facilities is extremely limited on the UAB campus. The only unit is a eight year old Sarastro instrument located in the Department of Neurobiology. This instrument, which is available on a restricted basis, is unsuitable for many of the applications described in this proposal because of its age and technical limitations including the fact that the unit is configured with an older microscope which yields a very low optical transfer efficiency. The availability of an instrument such as the Bio-Rad MRC-1024 on the UAB campus would have a major impact on the research programs of the nine NIH-funded investigators listed as primary users and provided a needed resourced for the broader UAB biomedical research community.