Targeting radiation driven invasion and metastasis in cancers of unmet need

点击翻译按钮获取中文摘要

Radiotherapy is used for a number of cancers, and while it is an effective and potentially curative treatment, it can induce unwanted behaviour in cancer cells that remain following therapy. One such behaviour is the induction of increased invasive potential, allowing cancers cells to disseminate and metastasise into normal tissue thus contributing to treatment resistance and recurrence.This project aims to identify new therapeutic avenues that can be used alongside radiotherapy to contain metastatic spread in three cancers: glioblastoma, colorectal cancer and pancreatic cancer. These cancers are currently of unmet need and novel, innovative therapies are urgently required to improve outcomes and survival rates. The work proposed will further our understanding of the processes that drive invasion and metastasis in these cancers, leading to the identification of novel anti-invasive, chemotherapeutic targets to improve patient outcomes in the future.