REGIONAL CEREBRAL CIRCULATION AND METABOLISM

区域脑循环和代谢

• 批准号: 6111106
• 负责人: LOUIS SOKOLOFF
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF MENTAL HEALTH
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6111106
• 关键词: Animalia; antipyrine; brain metabolism; deoxyglucose; glucose metabolism; magnetic resonance imaging; method development; positron emission tomography; radiotracer

This is an omnibus project that covers a number of studies on developmenting these methods to determine the basic chemical and physiological mechanisms that mediate the functional activation of brain blood flow and metabolism that are now used so extensively to study cognitive and other functions. Much of the work in this project during the last year has been directed at elucidating the chemical mechanisms of regulation of cerebral blood flow. These results have shown that adenosine receptors and K+ channels in vascular smooth muscle are involved and that adenosine production by alterations in brain tissue metabolism initiates a cascade of events that act on the adenosine receptors and ends in the opening of the K+ channels, membrane hyperpolarization, and smooth muscle relaxation in the cerebral blood vessel walls. Publications Dienel, G.A., Cruz, N.F., Adachi, K., Sokoloff, L., and Holden, J.E. (1997) Determination of local brain glucose level with [14C]methylglucose: Effects of glucose supply and demand. Am. J. Physiol. (Endocrinol. Metab. 36), 273: E839-E849. Takahashi, S., and Sokoloff, L. (1997) Role of nitric oxide in the regulation of cerebral blood flow in conscious rats. In: Ishimura, Y. (Ed.): Oxygen Homeostasis and its Dynamics, Springer-Verlag, Tokyo, pp. 545-563. Horinaka, N., Kuang, T-Y, Pak, H., Wang, R., Jehle, J., Kennedy, C., and Sokoloff, L. (1997) Blockade of cerebral blood flow response to insulin-induced hypoglycemia by caffeine and glibenclamide in conscious rats. J. Cereb. Blood Flow Metab 17: 1309-1318. In Press: Sokoloff, L., (In press) Mapping cerebral functional activity with radioactive deoxyglucose. In: Adelman, G., and Smith B., (Eds.): Encyclopedia of Neuroscience, Second Edition, Amsterdam, Elsevier. Clark, D.D. and Sokoloff, L. (In press) Circulation and energy metabolism of the brain. In: Siegel, G., Agranoff, B., Albers, R.W., and Fisher, S. (Eds.): Balsic Neurochemistry: Molecular, Cellular, and Medical Aspects, Sixth Edition, Lippincott-Raven, Philadelphia. Turkheimer, F., Sokoloff, L., Bertoldo, A., Lucignani, G., Reivich, M., Jaggi, L.J., and Schmidt, K. (In press) Estimation of uncertainty in components determined with spectral analysis. J. Cereb. Blood Flow Metab (accepted March 11, 1998). Sokoloff, L. (In press) Mechanisms of regulation of cerebral blood flow. In: Ito, U., Kirino, T., Kuroiwa, T., and Klatzo, I. (Eds.): Maturation Phenomenon in Cerebral Ischemia III. Defensive Mechanisms versus Apoptosis; Neuronal Recovery and Protection in Infarction, Springer, Berlin. Sokoloff, L. (In press) Energetics of functional activation in neural tissues. Neurochem. Res. (Accepted July 27, 1998). Sokoloff, L., Kuang, T-Y, Horinaka, N., and Kennedy, C. (In press) Are cerebral circulation and energy metabolism really tightly coupled? In: Krieglstein, J. (Ed.): Pharmacology of Cerebral Ischemia 1998. medpharm Scientific Publishers, Stuttgard, 1998. Madsen, P.L., Cruz, N.F., Sokoloff, L., and Dienel, G.A. (In press) Cerebral oxygen/glucose ratio is low during sensory stimulation and rises above normal during recovery: Excess glucose consumption during stimulation is not accounted for by lactate efflux from or accumulation in brain tissue. J. Cereb. Blood Flow Metab. (Accepted August 14, 1998).

这是一个综合性项目，涵盖了多个 发展这些方法测定土壤中的碱性物质的研究 调节功能的化学和生理机制 激活脑血流和新陈代谢，现在被用来 广泛研究认知和其他功能。世界上大部分的 在过去的一年里，这个项目的工作一直是针对 阐明脑血流调节的化学机制 流。这些结果表明，腺苷受体和K+ 血管平滑肌中的通道受累，腺苷 脑组织新陈代谢的变化产生的产物启动了 作用于腺苷受体的一系列事件，最终导致 K+通道开放，膜超极化，以及 脑血管壁的平滑肌松弛。 出版物Dienel，G.A.，Cruz，N.F.，Adachi，K.，Sokoloff，L.和 Holden，J.E.(1997)脑局部血糖水平的测定 [14C]甲基葡萄糖：葡萄糖供需的影响。上午好。J. 物理。(内分泌。梅塔布。36)，273：E839-E849。Takahashi，S. 和Sokoloff，L.(1997)一氧化氮在细胞周期调控中的作用 清醒大鼠的脑血流量。收录：石村，Y.(编辑)： 氧稳态及其动力学，施普林格-弗莱格，东京， 545-563页。首页--期刊主要分类--期刊细介绍--期刊题录与文摘-期刊详细文摘内容 J，Kennedy，C.和Sokoloff，L.(1997)大脑的阻断 咖啡因对胰岛素诱导的低血糖的血流反应 和格列本脲对清醒大鼠的影响。J·雷伯。血液流动Metab 17：1309-1318。出版：Sokoloff，L.，(印刷中)测绘大脑 放射性脱氧葡萄糖的功能活性。收录：阿德尔曼，G. 和史密斯B，(编辑)：神经科学百科全书，第二 版本，阿姆斯特丹，埃尔塞维尔。克拉克，D.D.和索科洛夫，L.(在 新闻)大脑的循环和能量代谢。收信人：西格尔 G，Aranoff，B.，Albers，R.W.和Fisher，S.(编辑)：Balsic 神经化学：分子、细胞和医学，第六期 利平科特-乌鸦版，费城。图克海默，F.，索科洛夫， L.，Bertoldo，A.，Lucignani，G.，Reivich，M.，Jaggi，L.J. 施密特，K.(在印)元件的不确定度估计 用光谱分析测定。J·雷伯。血液流动Metab (1998年3月11日获接纳)。索科洛夫，L.(印刷中)机构 调节脑血流量。收件人：伊藤，U，基里诺，T.，黑井， 和Klatzo，I.(编辑)：大脑中的成熟现象 脑缺血III.防御机制与细胞凋亡；神经元 《脑梗塞的康复与保护》，施普林格，柏林。索科洛夫 L.(正在出版)神经组织功能激活的能量学。 神经化学。决议(1998年7月27日接受)。Sokoloff，L.，Kuang， T-Y，Horinaka，N.和Kennedy，C.(印刷中)是大脑 循环和能量代谢真的紧密耦合吗？在： 克里格斯坦，J.(编)：脑缺血的药理学，1998。 医学科学出版社，斯图加德，1998。马德森，P.L. 科鲁兹，N.F.，索科洛夫，L.和迪内尔，G.A.(在印)大脑 在感觉刺激期间，氧/葡萄糖比率较低，然后上升 恢复期间高于正常水平：在恢复期间过量消耗葡萄糖 刺激不是由或的乳酸外流引起的 在脑组织中积聚。J·雷伯。血液流动Metab。 (1998年8月14日获接纳)。