Ivermectin Treatment of Livestock for Malaria Control on Sumba Island

松巴岛用伊维菌素治疗牲畜以控制疟疾

• 批准号: MR/V004670/1
• 负责人: Lorenz Von Seidlein
• 金额: $ 31.42万
• 依托单位: University of Oxford
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2021
• 资助国家: 英国
• 起止时间: 2021 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=MR%2FV004670%2F1
• 关键词: Ivermectin; Treatment; Livestock; Malaria; Control

Progress against malaria has stalled. New ways to control malaria are urgently needed to aid malaria elimination efforts both globally and in Indonesia. Ivermectin is a drug that can be safely given to humans or animals that makes their blood lethal to Anopheles mosquitoes that transmit malaria. It has been shown in Indonesia that ownership of livestock increases the risk of malaria transmission, and people on Sumba Island keep their livestock underneath their house, potentially attracting more Anopheles and increasing their risk of contracting malaria. We propose to treat livestock with ivermectin and evaluate how effective this is against wild Anopheles on Sumba. This control measure could interrupt the transmission of malaria if deployed on wide scale, and provide benefits of treating worm diseases in the farm animals. Additionally, we will engage the community to demonstrate the potential benefits of treating animals with ivermectin to thwart malaria. We will hold small meetings to gain the community, public health workers, and government officials' perspective on this potential control measure. Understanding the community perspective would allow us to develop the most effective ways to expand and achieve compliance with this control measure on Sumba and other areas of Indonesia. There are many Anopheles species on Sumba and we know very little about their feeding preferences for humans or livestock. We will use both human and livestock baited traps to characterize the feeding behavior of Anopheles on Sumba to gain a better understanding about how effective ivermectin treatment of livestock could be if implemented on Sumba. If positive results shown here, then this intervention could be reproduced throughout Indonesia and other areas of the world to eliminate malaria.

防治疟疾的工作停滞不前。迫切需要控制疟疾的新方法，以帮助全球和印度尼西亚消除疟疾的努力。伊维菌素是一种药物，可以安全地给予人类或动物，使他们的血液致命的按蚊传播疟疾。印度尼西亚的研究表明，拥有牲畜会增加疟疾传播的风险，松巴岛上的人们将牲畜饲养在房屋下面，这可能会吸引更多的按蚊并增加他们感染疟疾的风险。我们建议用伊维菌素治疗牲畜，并评估其对松巴野生按蚊的有效性。如果大规模部署，这种控制措施可以阻断疟疾的传播，并在农场动物中提供治疗蠕虫病的益处。此外，我们将让社区参与，以证明用伊维菌素治疗动物以阻止疟疾的潜在好处。我们将举行小型会议，以了解社区、公共卫生工作者和政府官员对这一潜在控制措施的看法。了解社区的观点将使我们能够制定最有效的方法，在松巴和印度尼西亚其他地区扩大和遵守这一控制措施。松巴岛上有许多按蚊物种，我们对它们对人类或牲畜的摄食偏好知之甚少。我们将使用人类和牲畜诱饵陷阱来描述Sumba上按蚊的摄食行为，以更好地了解如果在Sumba上实施伊维菌素治疗牲畜的有效性。如果这里显示出积极的结果，那么这种干预措施可以在印度尼西亚和世界其他地区复制，以消除疟疾。