ETHANOLS ACTIONS IN GAMMA PKC NULL MUTANTS

乙醇在 GAMMA PKC 无效突变体中的作用

基本信息

  • 批准号:
    2841998
  • 负责人:
  • 金额:
    $ 25.56万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    1999
  • 资助国家:
    美国
  • 起止时间:
    1999-03-01 至 2002-02-28
  • 项目状态:
    已结题

项目摘要

Protein phosphorylation is a basic regulator of cellular processes. One gene family, the calcium/lipid activated protein kinase C (PKC) encodes at least 11 isotypes. Among these isotypes the y-PKC isotype is the only PKC solely expressed in neurons of the brain and spinal cord. Until the creation of null mutant mice ("knock-outs") that carry a disrupted y-PKC gene, it has been difficult to analyze the role of specific isotypes in behavioral, biochemical, and physiological processes. We have previously demonstrated that y-PKC null mutants are less sensitive to the hypothermia-inducing and sedative-hypnotic effects of alcohol compared to their wild-type littermates. We provide data here showing that y-PKC mutants do not develop tolerance to some of alcohol's effects. Therefore, it appears that the y-isotype of PKC may play a role in the mediation of ethanol's action. The goal of this proposal is to investigate the role of y-PKC in determining behavioral responses to acute and chronic ethanol treatment. In specific aim #1, the y-PKC null mutants will be compared to mice that are either wild-type or heterozygous for the mutations using several measures of initial sensitivity and tolerance. In specific aim #2, transgenic mouse lines over-expressing y-PKC will be created and characterized for initial sensitivity and tolerance to ethanol. A genetic rescue of the y-PKC null mutants will also be performed by a genetic cross between transgenics and null mutants. The results of these studies will establish whether y-PKC plays a role in the pharmacological actions of ethanol that underlie the determination of ethanol sensitivity and tolerance.
蛋白质磷酸化是细胞过程的基本调节因子。一个

项目成果

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JEANNE M WEHNER其他文献

JEANNE M WEHNER的其他文献

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{{ truncateString('JEANNE M WEHNER', 18)}}的其他基金

Role of Nicotinic Receptors in Effects of Alcohol
烟碱受体在酒精作用中的作用
  • 批准号:
    6881433
  • 财政年份:
    2002
  • 资助金额:
    $ 25.56万
  • 项目类别:
Role of Nicotinic Receptors in Effects of Alcohol
烟碱受体在酒精作用中的作用
  • 批准号:
    7028986
  • 财政年份:
    2002
  • 资助金额:
    $ 25.56万
  • 项目类别:
Role of Nicotinic Receptors in Effects of Alcohol
烟碱受体在酒精作用中的作用
  • 批准号:
    6477753
  • 财政年份:
    2002
  • 资助金额:
    $ 25.56万
  • 项目类别:
Role of Nicotinic Receptors in Effects of Alcohol
烟碱受体在酒精作用中的作用
  • 批准号:
    6727463
  • 财政年份:
    2002
  • 资助金额:
    $ 25.56万
  • 项目类别:
Role of Nicotinic Receptors in Effects of Alcohol
烟碱受体在酒精作用中的作用
  • 批准号:
    6625624
  • 财政年份:
    2002
  • 资助金额:
    $ 25.56万
  • 项目类别:
GENETICS OF ALCOHOL AND SUBSTANCE ABUSE
酒精和药物滥用的遗传学
  • 批准号:
    6071234
  • 财政年份:
    1999
  • 资助金额:
    $ 25.56万
  • 项目类别:
BEHAVIORAL STUDIES OF NICOTINIC RECEPTOR NULL MUTANTS
烟碱受体无效突变体的行为研究
  • 批准号:
    6201624
  • 财政年份:
    1999
  • 资助金额:
    $ 25.56万
  • 项目类别:
BEHAVIORAL STUDIES OF NICOTINIC RECEPTOR NULL MUTANTS
烟碱受体无效突变体的行为研究
  • 批准号:
    6216560
  • 财政年份:
    1999
  • 资助金额:
    $ 25.56万
  • 项目类别:
ETHANOLS ACTIONS IN GAMMA PKC NULL MUTANTS
乙醇在 GAMMA PKC 无效突变体中的作用
  • 批准号:
    6163747
  • 财政年份:
    1999
  • 资助金额:
    $ 25.56万
  • 项目类别:
ETHANOLS ACTIONS IN GAMMA PKC NULL MUTANTS
乙醇在 GAMMA PKC 无效突变体中的作用
  • 批准号:
    6362171
  • 财政年份:
    1999
  • 资助金额:
    $ 25.56万
  • 项目类别:
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