GENDER, MODERATE ETHANOL INTAKE AND BONE METABOLISM

骨丢失和由此导致的骨量减少是导致骨量减少的重要原因 各种骨折的发病率随着年龄的增长而增加。是这样的 骨折不仅与立即增加的 发病率和死亡率，但对行动和死亡有长期影响 独立。这项建议的长期目标是研究 适量饮酒对男性骨代谢的影响 女性为了减少骨丢失和骨折的风险， 与饮酒有关。这项研究将评估 非酒精依赖者的酒精摄入量。该协议 将研究酒精摄入量和矿物质代谢参数 包括甲状旁腺激素(PTH)胶原分解产品 (DPC)、成骨细胞活性(骨钙素) 和维生素D浓度。协议将测量酒精含量 纵向摄入量和评估及其对男性骨密度的影响 并对女性进行评估。它们会有季节性的变化 参数被考虑在内。最后，该协议将检查 饮酒对大鼠股骨和腰椎骨密度变化的影响 男人和女人。我们预计男性患者的初始骨密度 适度饮酒的人会比最少饮酒的人少。 然而，在女性中，我们预计饮酒者的BMD更高 与饮酒量最低的人相比，这一比例适中。这 酒精对男性和女性的影响将会有所不同 性腺类固醇的类似变化也反映了这一点。这些将是 适量饮酒的男性减少，但女性增加 适度饮酒的人。

Bone loss and the resulting osteopenia contribute significantly to the increasing incidence of all kinds of fractures with age. Such fractures not only are associated with an immediate increase in morbidity and mortality, but have long term effects on mobility and independence. The long-term goal of this proposal is to study the effect is of moderate alcohol intake on bone metabolism in men and women in order to diminish the risk of bone loss and fracture which has been associated with alcohol intake. This study will evaluate alcohol intake in non-alcohol dependent individuals. The protocol will study alcohol intake and parameters of mineral metabolism including parathyroid hormone (PTH) collagen breakdown products (dipyrolidinium crosslinks) (DPC), osteoblast activity (osteocalcin) and vitamin D concentrations. The protocol will measure alcohol intake and evaluated longitudinally and their effect on BMD in men and women assessed. It will take seasonal variations of these parameters into account. Finally, the protocol will examine the effect of alcohol intake on changes in femoral and lumbar BMD in men and women. We expect that the initial BMD in men who drink moderately will be less than in those who drink minimally. In women, however, we expect greater BMD in those who drink moderately compared to those who drink minimally. This difference in the effects of alcohol on men and women will be mirrored by similar changes in gonadal steroids. These will be decreased in men who drink moderately, but increased in women who drink moderately.