GENDER, MODERATE ETHANOL INTAKE AND BONE METABOLISM

性别、适量乙醇摄入量和骨代谢

• 批准号: 2894146
• 负责人: HORACE M PERRY
• 金额: $ 20.84万
• 依托单位: SAINT LOUIS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-09-01 至 2002-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2894146
• 关键词: alcoholic beverage consumption; body composition; bone density; bone metabolism; calcium metabolism; clinical research; diet; dietary calcium; disease /disorder proneness /risk; female; hormone regulation /control mechanism; human subject; nutrition related tag; osteoporosis; parathyroid hormones; phosphorus metabolism; postmenopause; sex hormones

Bone loss and the resulting osteopenia contribute significantly to the increasing incidence of all kinds of fractures with age. Such fractures not only are associated with an immediate increase in morbidity and mortality, but have long term effects on mobility and independence. The long-term goal of this proposal is to study the effect is of moderate alcohol intake on bone metabolism in men and women in order to diminish the risk of bone loss and fracture which has been associated with alcohol intake. This study will evaluate alcohol intake in non-alcohol dependent individuals. The protocol will study alcohol intake and parameters of mineral metabolism including parathyroid hormone (PTH) collagen breakdown products (dipyrolidinium crosslinks) (DPC), osteoblast activity (osteocalcin) and vitamin D concentrations. The protocol will measure alcohol intake and evaluated longitudinally and their effect on BMD in men and women assessed. It will take seasonal variations of these parameters into account. Finally, the protocol will examine the effect of alcohol intake on changes in femoral and lumbar BMD in men and women. We expect that the initial BMD in men who drink moderately will be less than in those who drink minimally. In women, however, we expect greater BMD in those who drink moderately compared to those who drink minimally. This difference in the effects of alcohol on men and women will be mirrored by similar changes in gonadal steroids. These will be decreased in men who drink moderately, but increased in women who drink moderately.

骨丢失和由此导致的骨质减少显著地促成了 随着年龄的增长，各种骨折的发生率都在增加。 等 骨折不仅会立即增加 发病率和死亡率，但对流动性有长期影响， 独立 这项建议的长远目标是研究 适量饮酒对男性骨代谢的影响， 为了减少骨质流失和骨折的风险， 与酒精摄入有关 本研究将评估 非酒精依赖者的酒精摄入量。 议定书 将研究酒精摄入量和矿物质代谢参数 包括甲状旁腺激素（PTH）胶原分解产物 （二吡咯烷鎓交联）（DPC），成骨细胞活性（骨钙素） 和维生素D浓度。 该方案将测量酒精含量 摄入量和纵向评价及其对男性骨密度的影响 女性评价 这将需要这些季节性变化 参数考虑。 最后，协议将检查 酒精摄入对老年人股骨和腰椎骨密度变化的影响 男人和女人 我们认为， 适量饮酒的人会比那些喝得最少的人少。 然而，在女性中，我们预计饮酒者的BMD更高 与饮酒量最少的人相比， 这 酒精对男性和女性影响的差异将是 性腺类固醇也有类似的变化 这些将是 适度饮酒的男性减少，但女性增加 适度饮酒的人