GENES OF HYPERTENSION IN AFRICAN AMERICANS

非裔美国人的高血压发病率高出近50% 与白种人相比，与更高的发病率相关， 中风、心力衰竭和终末期肾病的死亡率。 研究旨在确定与高血压共分离的基因 以及与非裔美国人高血压相关的表型。 将使用全基因组搜索和候选基因方法。到 狭义遗传异质性，我们将确定400名非裔美国人同胞 年龄在18-55岁之间的高血压患者， 高胆固醇血症对其中200对同胞兄弟姐妹进行广泛的表型分析 将进行鉴定生理机制的遗传位点 可能导致高血压表型研究将评估 肾功能、肾和外周血管反应性、胰岛素 敏感性和红细胞中的离子转运。为了确定基因 发现与高血压有关， 压力，一个有患高血压风险的队列 （来自“受影响”罪孽家庭的血压正常罪孽）将是基因型 在3-4年内重复测量血压。最后，DNA 将从150名血压正常、血脂正常的非裔美国人中收集 用于数量性状基因座（QTL）的关联研究（病例对照） 在受影响的同胞对中发现与高血压共分离 study.

The incidence of hypertension in African Americans is nearly 50% higher than in Caucasians and is associated with higher rates of morbidity and mortality from stroke, heart failure, and end-stage renal disease. Studies are designed to identify genes that cosegregate with hypertension and with phenotypes associated with hypertension in African Americans. Both a genome wide search and a candidate gene approach will be used. To narrow genetic heteogeneity, we will identify 400 African American sib pairs, 18-55 years of age, who are hypertensive and also hypercholesterolemic. Extensive phenotyping of 200 of these sib pairs will be carried out to identify genetic loci of physiologic mechanisms that may contribute to hypertension. Phenotypic studies will evaluate renal function, renal and peripheral vascular reactivity, insulin sensitivity, and ion transport in erythrocytes. To determine if genes found to be associated with hypertension predict an increase of blood pressure, a cohort that is at risk for developing hypertension (normotensive sins from families of the 'affected' sins) will be genotype with repeat measurements of blood pressure in 3-4 years. Finally, DNA will be collected from 150 normotensive, normolipidemic African Americans for an association study (case control) for quantitative trait loci (QTL) which are found to cosegregate with hypertension in the affected sib pair study.