CHRONIC CENTRAL PAIN AFTER SPINAL CORD INJURY

脊髓损伤后的慢性中枢性疼痛

• 批准号: 6204986
• 负责人: CLAIRE E HULSEBOSCH
• 金额: $ 10.35万
• 依托单位: UNIVERSITY OF TEXAS MED BR GALVESTON
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-08-01 至 2000-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6204986
• 关键词: afferent nerve; behavioral habituation /sensitization; chronic disease /disorder; circadian rhythms; disease /disorder model; dorsal horn; electrophysiology; excitatory aminoacid; laboratory rat; microdialysis; neuroanatomy; neurons; neuropharmacology; neuropsychological tests; neurotransmitters; pain; spinal cord injury; statistics /biometry

It is the long-term objective of this laboratory to improve functional outcome after spinal cord injury (SCI). One important issue is the chronic pain sensations that the majority of patients with SCI experience. This project focuses on the development of a mammalian model of chronic central pain that is reproducible and has both spontaneous and evoked pain components, an important contribution which will allow an investigation of mechanisms and possible therapeutic interventions. There are four hypotheses to be tested: 1. Spinal cord injury produces chronic pain which can be measured as alterations in evoked behaviors. 2. Excitatory amino acids (EAA) and peptides play important roles in the alterations of evoked somatosensory behavior observed after spinal cord hemisection. 3. EAAs and peptides play an important role in central sensitization of dorsal horn neurons in nociceptive pathways in this SCI model. 4. Spinal cord injury produces chronic pain which can be measured as alterations in spontaneous, non-evoked behavior. Methods include behavioral tests, electrophysiological recordings, microdialysis and behavioral outcome of pharmacological intervention. These data will contribute toward understanding the symptomology and behavioral changes characteristic of partially spinalized patients.

该实验室的长期目标是提高功能 脊髓损伤后的结局（SCI）。 一个重要的问题是 大多数SCI经验患者的慢性疼痛感觉。 该项目重点是开发慢性哺乳动物模型 可重复的中心疼痛，既有自发和诱发的疼痛 组件，一个重要的贡献，将允许调查 机制和可能的治疗干预措施。 有四个 要测试的假设： 1。脊髓损伤会产生慢性疼痛，可以测量 诱发行为的改变。 2。兴奋性氨基酸（EAA）和肽在 脊髓后观察到的诱发体感行为的改变 半分。 3。EAA和肽在中央敏化中起重要作用 该SCI模型中的伤害感受途径中的背角神经元。 4。脊髓损伤会产生慢性疼痛，可以测量 自发，非诱发行为的改变。 方法包括行为测试，电生理记录， 药理学干预的微透析和行为结果。 这些数据将有助于理解症状和 部分脊柱脊柱的患者的行为变化特征。