CORE--ANALYTICAL AND MODELING

核心——分析和建模

• 批准号: 6110906
• 负责人: JOSEPH B PATLAK
• 金额: $ 25.3万
• 依托单位: UNIVERSITY OF VERMONT & ST AGRIC COLLEGE
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-02-18 至 2000-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6110906
• 关键词: actins; biomedical facility; chemical models; computer data analysis; computer simulation; data collection; model design /development; myosins; protein structure function

This core is designed to provide an analytical underpinning to the quantitative efforts of all the projects. The ultimate goal is to distal the vast amount of raw biophysical and biochemical data generated by the individual projects into a single unifying model of several highly complementary models that will enhance our understanding of both FHC and the molecular structure function relationships for the various contractile proteins. To achieve this goal, state-of-the-art data analysis, complex computer-based modeling, and effective communication of the results will be required. Each project depends upon computational activities. In some, computers are fundamental to the gathering and processing of raw data, in others they support the visualization of molecular structures, storage and manipulation of genetic codes, etc. Although the development and maintenance of computer-oriented applications is now part of each laboratory's individual efforts, that current paradigm also causes significant duplication of effort. Since the members of the core must, by the nature of their work, maintain an advanced working knowledge of hardware and software applications, his expertise can be efficiently shared with all the projects as part of the core. The proposed design of the core would provide substantive effort in developing: 1) models and simulations related to individual projects; 2) a quantitative basis for translating data between various project- specific models; 3) new methods for data analysis and visualization;

该核心旨在为 所有项目的量化工作。最终目标是远端 大量的原始生物物理和生物化学数据产生的 将单个项目整合到一个统一的模型中， 补充模型，这将提高我们对FHC和 不同收缩因子的分子结构与功能关系 proteins.为了实现这一目标，最先进的数据分析，复杂的 基于计算机的建模，以及结果的有效交流将 被要求。 每个项目都依赖于计算活动。在某些情况下，计算机 收集和处理原始数据的基础，在其他方面， 支持分子结构的可视化，存储和 操纵遗传密码等，虽然发展和 面向计算机的应用程序的维护现在是每个 实验室个人努力，目前的范式也导致 严重的重复劳动。由于核心成员必须通过 他们的工作性质，保持先进的工作知识， 硬件和软件应用程序，他的专业知识可以有效地 作为核心的一部分与所有项目共享。 拟议的核心设计将提供实质性的努力， 开发： 1)与个别项目有关的模型和模拟; 2)在不同项目之间转换数据的定量基础- 具体模式; 3)数据分析和可视化的新方法;