TRAINING IN THE MOLECULAR BASIS OF MUSCLE CONTRACTION

（改编自申请人摘要）在分子生物学系 佛蒙特大学的生理学和生物物理学， 长期以来，研究人员一直把工作重点放在肌肉的机制上， 收缩。 新方法，包括分子遗传学、蛋白质 晶体学、单分子力学和肌球蛋白荧光研究 扩大了这项研究的深度和广度。 额外 研究人员将他们的工作致力于 基于运动蛋白的疾病（例如家族性肥大性 心肌病）。 这个多学科和多部门的集群， 因此，实验室既跨越又整合了对肌肉的研究， 从单个分子到整个生物体的机制。 这一组形成了一个“梦想”的环境，无论是在训练前， 博士后水平，与“下大厅”获得了前所未有的频谱 最先进的方法和世界级的专业知识。 正在进行 与生理学系并与其他系合作开展活动 部门，提供持续的研究职业发展的环境。 除了常规的研究生课程外，申请人还有几个正在进行的课程。 在特定重点领域定期开会的研究小组。 虽然 该小组多年来还积极培训新的调查人员， 这个项目的规模一直很小。 目前有5名毕业生 学生和4名博士后研究员在18个完全建立的 这些实验室组成了这个项目。 建议通过以下方式增加青年研究人员的参与： 在分子基础上制定专门针对性的培训计划， 肌肉收缩。申请人申请了三个职位， 毕业生，谁将加入现有的博士学位。程序内的 分子生理学和生物物理学系，为期4-5年。 在 此外，他们正在寻求支持4名博士后加入 个别实验室，并促进小组的互动， 开发跨越不同实验室的项目。

(Adapted from applicant's abstract) Within the Department of Molecular Physiology and Biophysics at the University of Vermont, a core group of researchers has long focused their work on the mechanisms of muscle contraction. New approaches, including molecular genetics, protein crystallography, single molecule mechanics, and myosin fluorescence studies have expanding both the depth and the breadth of this research. Additional perspectives are brought by investigators dedicating their work to the mechanisms of motor-protein based disease (for example Familial Hypertrophic Cardiomyopathy). This multidisciplinary and multidepartmental cluster of laboratories therefore both spans and integrates investigations of muscle mechanisms from individual molecules through whole organisms. This group forms a "dream" environment for training at either the pre- or postdoctoral level, with "down-the-hall" access to an unprecedented spectrum of state-of-the-art methodologies and world-class expertise. Ongoing activities with the Department of Physiology, and in collaboration with other departments, provide an environment for continued research career development. Besides the regular graduate courses, the applicants have several ongoing study groups that meet regularly in specifically focusses areas. Although this group has also been active for many years in training new investigators, the size of the program has always been small. They currently have 5 graduate students and 4 post-doctoral fellows working within the 18 fully established laboratories that constitute this program. It is proposed here to increase the participation of young researchers by developing a specifically targeted training program in the molecular basis of muscle contraction. The applicants are requesting three positions for pre- graduate trainees, who will join the existing Ph.D. program within the Department of Molecular Physiology and Biophysics for a 4-5 year program. In addition, they are seeking support for 4 postdoctoral fellows to join individual laboratories, and to facilitate the interactivity of the group by developing projects that span different labs.