TRAINING IN THE MOLECULAR BASIS OF MUSCLE CONTRACTION

(改编自申请者的摘要)在分子系 佛蒙特大学的生理学和生物物理学 长期以来，研究人员一直将工作重点放在肌肉的机制上。 收缩。新的方法，包括分子遗传学，蛋白质 结晶学、单分子力学和肌球蛋白荧光研究 拓展了本研究的深度和广度。其他内容 调查人员将他们的工作致力于 以运动蛋白为基础的疾病的机制(例如，家族性肥厚 心肌病)。这一多学科、多部门的集群 因此，实验室既包括肌肉研究，也包括肌肉研究。 从单个分子到整个有机体的机制。 这群人形成了一个梦想的环境，无论是在预赛阶段还是在预赛阶段 博士后水平，可以接触到前所未有的光谱 最先进的方法和世界级的专业知识。正在进行中 与生理系的活动，并与其他 系，为持续的研究事业发展提供环境。 除了常规的研究生课程外，申请者还有几个正在进行的课程 定期在特定的重点领域举行会议的学习小组。虽然 多年来，该小组还积极培训新的调查人员， 该计划的规模一直很小。他们目前有5名毕业生 在18个正式编制内工作的学生和4名博士后研究员 组成这一计划的实验室。 这里建议通过以下方式增加青年研究人员的参与 在分子基础上制定特别有针对性的培训计划 肌肉收缩。应聘者正在申请三个职位的预科- 毕业实习生，谁将参加现有的博士课程 分子生理学和生物物理学系，攻读4-5年。在……里面 此外，他们正在寻求支持4名博士后研究员加入 各个实验室，并通过以下方式促进小组的互动 开发跨越不同实验室的项目。

(Adapted from applicant's abstract) Within the Department of Molecular Physiology and Biophysics at the University of Vermont, a core group of researchers has long focused their work on the mechanisms of muscle contraction. New approaches, including molecular genetics, protein crystallography, single molecule mechanics, and myosin fluorescence studies have expanding both the depth and the breadth of this research. Additional perspectives are brought by investigators dedicating their work to the mechanisms of motor-protein based disease (for example Familial Hypertrophic Cardiomyopathy). This multidisciplinary and multidepartmental cluster of laboratories therefore both spans and integrates investigations of muscle mechanisms from individual molecules through whole organisms. This group forms a "dream" environment for training at either the pre- or postdoctoral level, with "down-the-hall" access to an unprecedented spectrum of state-of-the-art methodologies and world-class expertise. Ongoing activities with the Department of Physiology, and in collaboration with other departments, provide an environment for continued research career development. Besides the regular graduate courses, the applicants have several ongoing study groups that meet regularly in specifically focusses areas. Although this group has also been active for many years in training new investigators, the size of the program has always been small. They currently have 5 graduate students and 4 post-doctoral fellows working within the 18 fully established laboratories that constitute this program. It is proposed here to increase the participation of young researchers by developing a specifically targeted training program in the molecular basis of muscle contraction. The applicants are requesting three positions for pre- graduate trainees, who will join the existing Ph.D. program within the Department of Molecular Physiology and Biophysics for a 4-5 year program. In addition, they are seeking support for 4 postdoctoral fellows to join individual laboratories, and to facilitate the interactivity of the group by developing projects that span different labs.