QUANTITATIVE IMAGING OF CEREBRAL BLOOD FLOW AND OXYGEN CONSUMPTION

本项目的主要目的是开发新的磁共振（MR） 用于对人类的脑血流（CBF）进行成像的“自旋标记”方法， 并将这些方法应用于研究生理和药理学 精神病患者的功能障碍。 新的MR方法使用经典的 基于Kety-Schmidt方程的示踪理论，但不是使用 放射性示踪剂，它们使用稳定的扰动磁自旋状态 同位素 该项目的前期工作确定了一些主要的 排除定量脑血计算的问题 人类的心流价值观，并开发了理论方法论方法 来克服这些问题。 在过去的一年中，CBF成像方法已经通过使用 联合MR/PET研究，并已应用于研究区域性增加 在运动和认知激活模式中的脑血流量。 为 例如，在初级感觉运动皮层中CBF的平均增加， 运动任务为60 + - 10 cc/100 g/min（91%），而平均增加 在工作记忆任务中，前额叶皮层的CBF为22 +/-5 cc/100g/min（23%）。 今后两年的工作重点是研究 精神病患者的局部脑功能障碍。

The major aim of this project is to develop new magnetic resonance (MR) "spin tagging" approaches for imaging cerebral blood flow (CBF) in humans, and to apply these approaches to study physiological and pharmacological dysfunction in psychiatric patients. The new MR approaches use classical tracer theory based on the Kety-Schmidt equation, but instead of using radioactive tracers they use perturbed magnetic spin states of stable isotopes. Previous work in this project identified a number of major problems that had precluded the calculation of quantitative cerebral blood flow values in humans, and developed theoretical methodological approaches for overcoming these problems. During the last year the CBF imaging approaches have been validated using a combined MR/PET study, and have been applied to study regional increases in cerebral blood flow in motor and cognitive activation paradigms. For example, the average increase in CBF in primary sensorimoter cortex during motor tasks was 60 + - 10 cc/100g/min (91%), while the average increase in CBF in prefrontal cortex during working memory tasks was 22 +/- 5 cc/100g/min (23%). Work in the upcoming two years will focus on the study of regional cerebral dysfunction in psychiatric patients.