QUANTITATIVE IMAGING OF CEREBRAL BLOOD FLOW AND OXYGEN CONSUMPTION

脑血流和耗氧量的定量成像

• 批准号: 6290577
• 负责人: Alan CHARLES McLaughlin
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF MENTAL HEALTH
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6290577
• 关键词: biomedical equipment development; blood flow measurement; brain circulation; brain disorder diagnosis; brain imaging /visualization /scanning; brain metabolism; clinical biomedical equipment; clinical research; diagnosis design /evaluation; human subject; magnetic resonance imaging; mathematical model; method development; noninvasive diagnosis; oxygen consumption; schizophrenia

The major aim of this project is to develop new magnetic resonance (MR) spin tagging approaches for imaging cerebral blood flow (CBF) in humans, and to apply these approaches to study physiological and pharmacological dysfunction in psychiatric patients. The new MR approaches use classical tracer theory, but instead of using radioactive tracers they use perturbed magnetic spin states of stable isotopes. Previous work in this project: (1) identified a number of major problems that had precluded the calculation of quantitative cerebral blood flow values in humans, and developed theoretical and methodological approaches for overcoming these problems; (2) extended and revised preliminary PET validation experiments; (3) developed a new tracer kinetic model that accounts for restricted diffusion of water across the blood brain barrier; (4) developed three-dimensional arterial spin tagging approaches that can be used to study regional activation during motor activation tasks. These three-dimensional approaches solve many of the problems inherent in using two-dimensional approaches for activation studies, and also allow better spatial resolution. In the last year new technical approaches have been developed that allow better sensitivity, and the three-dimensional arterial spin tagging approaches have been extended to study regional activation during cognitive tasks. In the next few years these experiments will be extended to study the effects of inhibitors of specific biochemical and pharmacological pathways on the cognitive activation process, and will ultimately be applied to quantitate cerebral dysfunction in psychiatric patients. - MRI, fMRI, cerebral blood flow, cerebral activation, motor activation, cognitive activation - Human Subjects

该项目的主要目的是开发新的磁共振（MR）自旋标记方法来成像人类脑血流（CBF），并应用这些方法来研究精神病患者的生理和药理功能障碍。新的MR方法使用经典示踪剂理论，但不是使用放射性示踪剂，而是使用稳定同位素的扰动磁自旋态。本项目以前的工作：（1）确定了一些主要问题，这些问题阻碍了定量计算人类脑血流量值，并开发了克服这些问题的理论和方法学方法;（2）扩展和修订了初步PET验证实验;（3）开发了一种新的示踪剂动力学模型，该模型考虑了水穿过血脑屏障的限制扩散;（4）开发了三维动脉自旋标记方法，可用于研究运动激活任务期间的区域激活。这些三维方法解决了许多使用二维方法进行激活研究所固有的问题，并且还允许更好的空间分辨率。在过去的一年中，新的技术方法已经开发出来，允许更好的灵敏度，和三维动脉自旋标记方法已被扩展到研究区域激活认知任务。在接下来的几年里，这些实验将扩展到研究特定生化和药理学途径的抑制剂对认知激活过程的影响，并最终应用于定量精神病患者的脑功能障碍。- MRI、fMRI、脑血流量、脑激活、运动激活、认知激活-人类受试者