TSES 易感动物 PRP 基因的分子遗传学分析-猫眼课题宝

TSES 易感动物 PRP 基因的分子遗传学分析

批准号：

6111966

负责人：

L CERVENAKOVA

金额：

$0.0万

依托单位：

NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

依托单位国家：

美国

项目类别：

财政年份：

资助国家：

美国

项目状态：

未结题

起止时间：

至

来源：

https://reporter.nih.gov/project-details/6111966

关键词：

Macaca mulatta Ungulate communicable disease transmission genetic polymorphism molecular genetics neurogenetics prions protein sequence spongiform encephalopathy

项目摘要

项目成果

L CERVENAKOVA的其他基金

相似基金

相关文献

中文摘要

翻译

点击翻译按钮获取中文摘要

英文摘要

Mule deer and Rocky Mountain elk develop chronic wasting disease that belongs to the group of transmissible spongiform encephalopathies (TSEs). The PrP gene coding region has been analyzed in mule deer and Rocky Mountain elk. The predicted amino acid sequence of PrP was nearly identical (99.6%) between two species, with only a single difference at codon 226 (glutamine and glutamic acid, respectively). A polymorphism at codon 138 (serine to asparagine) has been detected in mule deer PrP gene coding region. Further investigation is underway to establish if this polymorphism plays a role in susceptibility of mule deer to chronic wasting disease. Analysis of 300 transmissions of different forms of TSEs to nonhuman primates revealed that rhesus monkeys had the lowest rate of successful transmission. Analysis of the PRNP gene has been initiated to elucidate the role of genetic factors in susceptibility of rhesus monkeys to TSE.

期刊论文(0)

专著(0)

科研奖励(0)

会议论文