MOLECULAR GENETIC ANALYSIS OF THE PRP GENE IN ANIMAL SPECIES SUSCEPTIBLE TO TSES

骡鹿和落基山脉麋鹿会患上慢性消耗性疾病 属于传染性海绵状脑病的一组 (TSE)。对马鹿和马鹿PrP基因编码区进行了分析 落基山麋鹿。预测的PrP的氨基酸序列接近于 两个物种之间的相同(99.6%)，只有一个差异 密码子226(分别为谷氨酰胺和谷氨酸)。A多态 在马鹿PrP中检测到第138位密码子(丝氨酸到天冬酰胺) 基因编码区。进一步的调查正在进行中，以确定 这种多态在马鹿对慢性疾病的易感性中起到了作用。 消耗性疾病。300例不同形式的变速箱分析 对非人类灵长类动物的TSE显示，猕猴的这一比例最低 传输成功的速率。对PRNP基因的分析已经完成 开始阐明遗传因素在糖尿病易感性中的作用 恒河猴到谢天谢地。

Mule deer and Rocky Mountain elk develop chronic wasting disease that belongs to the group of transmissible spongiform encephalopathies (TSEs). The PrP gene coding region has been analyzed in mule deer and Rocky Mountain elk. The predicted amino acid sequence of PrP was nearly identical (99.6%) between two species, with only a single difference at codon 226 (glutamine and glutamic acid, respectively). A polymorphism at codon 138 (serine to asparagine) has been detected in mule deer PrP gene coding region. Further investigation is underway to establish if this polymorphism plays a role in susceptibility of mule deer to chronic wasting disease. Analysis of 300 transmissions of different forms of TSEs to nonhuman primates revealed that rhesus monkeys had the lowest rate of successful transmission. Analysis of the PRNP gene has been initiated to elucidate the role of genetic factors in susceptibility of rhesus monkeys to TSE.