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HYPONATREMIA OF MALIGNANCY

HYPONATREMIA OF MALIGNANCY
恶性肿瘤低钠血症
批准号：
6163433
负责人：
B E JOHNSON
金额：
$0.0万
依托单位：
DIVISION OF CLINICAL SCIENCES - NCI
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/6163433
关键词：
RNase protection assay atrial natriuretic peptide clinical research hormone regulation /control mechanism human subject human therapy evaluation hyponatremia low salt diet lung neoplasms neoplasm /cancer genetics pathologic process relapse /recurrence tissue /cell culture

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英文摘要
"""DISCONTINUED"". The Lung Cancer Biology Section has undertaken two prospective trials to study the role of ectopic production of arginine vasopressin and atrial natriuretic peptide in 64 patients with lung cancer. These studies were undertaken to define the impact of these hormones on sodium homeostasis as well as the renin, angiotensin, and aldosterone system. Fifty patients, 31 with small cell lung cancer and 19 with non-small cell lung cancer participated in the initial clinical trial. Eleven patients presented with hyponatremia; 10 patients with small cell lung cancer (32%) and 1 patient with non-small cell lung cancer. All 11 patients who presented with hyponatremia had inappropriately elevated levels of AVP. Elevated plasma AVP levels were highly correlated with the presence of hyponatremia (p"
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IN VITRO DRUG TESTING FOR LIMITED SCLC AND PHASE I DRUG DEVELOPMENT
  • 批准号：
    3939554
  • 项目类别：
  • 资助金额：
    $0.0万
  • 财政年份：
    --
  • 负责人：
    B E JOHNSON
  • 依托单位：
    DIVISION OF CANCER TREATMENT
MOLECULAR GENETIC EVENTS IN LUNG CANCER
  • 批准号：
    3838085
  • 项目类别：
  • 资助金额：
    $0.0万
  • 财政年份：
    --
  • 负责人：
    B E JOHNSON
  • 依托单位：
    DIVISION OF CANCER TREATMENT
IN VITRO DRUG TESTING FOR LIMITED SCLC AND PHASE I DRUG DEVELOPMENT
  • 批准号：
    3916620
  • 项目类别：
  • 资助金额：
    $0.0万
  • 财政年份：
    --
  • 负责人：
    B E JOHNSON
  • 依托单位：
    DIVISION OF CANCER TREATMENT
MOLECULAR GENETIC EVENTS IN LUNG CANCER
  • 批准号：
    3916618
  • 项目类别：
  • 资助金额：
    $0.0万
  • 财政年份：
    --
  • 负责人：
    B E JOHNSON
  • 依托单位：
    DIVISION OF CANCER TREATMENT
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