CORE--TRAINING AND CLINICAL FACILITY

该核心将履行两项相互关联的职能。它会训练 医生谁完成了他们的神经病学住院医师在这两个 帕金森病和其他疾病患者的评估和管理 运动障碍和适用于运动障碍研究的科学技术 帕金森病的病理生理学。它还将建立一个临床 核心，将支持临床（项目#2）和实验 神经病理学（项目#1和#3）研究在此提出 中心以及提供了一个来源，以及表征帕金森氏症 疾病患者的研究项目，不直接参与其中， 中心为此，我们将： 1)检查，诊断，并登记在PD患者登记男性和女性 PD和相关帕金森综合征患者和健康对照受试者 在年龄、性别和社会地位方面与患者相匹配， 经济地位; 2)描述神经学、功能学和神经心理学 PD的特征，以确保临床诊断和允许 PD的生前特征与死后发现之间的相关性; 3)将这些经过仔细评估的PD患者和对照受试者转诊至 拨款中所述的具体临床研究项目（项目 #2，布雷克菲尔德博士，PI）和正式项目以外的资助项目 中心; 4)从入组PD患者的受试者中获得脑捐赠 登记处;处理、诊断和存储收到的每个大脑;以及 将脑组织提交给项目1（Hyman博士，PI）和项目3（Hyman博士，PI）。 Penny，PI）和正式中心以外的资助项目。

This core will perform two interrelated functions. It will train physicians who have completed their neurology residencies in both the evaluation and management of patients with Parkinson's disease and other movement disorders and in scientific techniques applicable to the study of Parkinson's disease pathophysiology. It will also establish a clinical core that will support the clinical (project #2) and experimental neuropathological (projects #1 and #3) research studies proposed in this center as well as provides a source of well characterized Parkinson's disease patients for research projects that are not directly part of this center. To accomplish this we will: 1) Examine, diagnose, and enroll in a PD Patient Registry men and women with PD and related parkinsonian syndromes, and healthy control subjects who are matched to the patients with respect to age, gender, and socio- economic status; 2) Characterize the neurological, functional, and neuropsychological features of PD in order to secure the clinical diagnosis and permit correlations between antemortem features of PD and postmortem findings; 3) Refer these carefully evaluated PD patients, and control subjects, to the specific clinical research projects described in the grant (project #2, Dr. Breakefield, PI) and to funded projects outside of the formal center; 4) To obtain brain donations from subjects enrolled in the PD Patient Registry; to process, diagnose and store each brain received; and to submit brain tissue to project #1 (Dr. Hyman, PI) and project #3 (Dr. Penny, PI) and to funded projects outside of the formal center.