CORE--TRAINING AND CLINICAL FACILITY

核心——培训和临床设施

• 批准号: 6112671
• 负责人: John B Penney
• 金额: $ 2.89万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-09-30 至 1999-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6112671
• 关键词: Parkinson's disease; biomedical facility; continuing education; education evaluation /planning

This core will perform two interrelated functions. It will train physicians who have completed their neurology residencies in both the evaluation and management of patients with Parkinson's disease and other movement disorders and in scientific techniques applicable to the study of Parkinson's disease pathophysiology. It will also establish a clinical core that will support the clinical (project #2) and experimental neuropathological (projects #1 and #3) research studies proposed in this center as well as provides a source of well characterized Parkinson's disease patients for research projects that are not directly part of this center. To accomplish this we will: 1) Examine, diagnose, and enroll in a PD Patient Registry men and women with PD and related parkinsonian syndromes, and healthy control subjects who are matched to the patients with respect to age, gender, and socio- economic status; 2) Characterize the neurological, functional, and neuropsychological features of PD in order to secure the clinical diagnosis and permit correlations between antemortem features of PD and postmortem findings; 3) Refer these carefully evaluated PD patients, and control subjects, to the specific clinical research projects described in the grant (project #2, Dr. Breakefield, PI) and to funded projects outside of the formal center; 4) To obtain brain donations from subjects enrolled in the PD Patient Registry; to process, diagnose and store each brain received; and to submit brain tissue to project #1 (Dr. Hyman, PI) and project #3 (Dr. Penny, PI) and to funded projects outside of the formal center.

这个核心将执行两个相互关联的功能。它将会训练 已完成神经科住院医师培训的医生 帕金森病及其他疾病患者的评估和处理 运动障碍和适用于研究运动障碍的科学技术 帕金森氏病病理生理学。它还将建立一个临床 将支持临床(项目2)和实验的核心 本报告中提出的神经病理学(项目1和3)研究 中心，并提供了一个特征良好的帕金森氏症的来源 疾病患者的研究项目，这些项目不是该项目的直接组成部分 中间。要做到这一点，我们将： 1)检查、诊断和登记PD患者登记处 帕金森病及相关帕金森综合征患者和健康对照组 在年龄、性别和社会方面与患者匹配的人- 经济地位； 2)描述神经学、功能性和神经心理学 帕金森病的特点，以确保临床诊断和许可 帕金森病的生前特征与尸检结果的相关性； 3)将这些经过仔细评估的PD患者和对照受试者转介到 资助(项目)中所述的具体临床研究项目 #2，Breakefield博士，PI)和资助的项目以外的正式 中心； 4)从帕金森病患者登记的受试者那里获得脑捐赠 注册；处理、诊断和存储接收到的每个大脑；以及 将脑组织提交给项目1(海曼博士，Pi)和项目3(Dr。 Penny，PI)，并资助正式中心以外的项目。