Born in Scotland in the 2020s - Pilot study
Born in Scotland in the 2020s - Pilot study
批准号:
MR/V034294/1
负责人:
Rebecca Reynolds
金额:
$112.09万
依托单位:
依托单位国家:
英国
项目类别:
Research Grant
财政年份:
2021
资助国家:
英国
项目状态:
未结题
起止时间:
2021 至 --
中文摘要
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英文摘要
Pregnancy offers a unique opportunity to positively impact on short- and long-term health outcomes of both the mother and baby and thus to influence the health of the next generation. In this study, we aim to conduct a pilot study to demonstrate the feasibility of establishing a large population study of 100,000 pregnant women and their children, recruited from across the whole of Scotland. The pilot study will pave the way for a new "Born in Scotland in the 2020s" cohort which will gather and safely store routinely collected clinical, health and social data from hospitals, schools and others sources. This confidential data will then be then anonymised so that individual participants cannot be identified before data analysis. We will also store blood and urine samples which are left over and normally thrown away after they have been used for diagnostic purposes. We will link these samples to the other data to establish a unique bioresource which can be used to identify new biomarkers for adverse pregnancy outcomes. Our study will allow us to understand the links between early life experiences and later ill health and to identify novel targets for intervention to improve outcomes for pregnant women and their children. The rich and extensive data collected will be a valuable and sustainable resource for researchers in the field.
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DOI:
10.1038/s41598-023-44619-0
发表时间:
2023-10-21
期刊:
SCIENTIFIC REPORTS
影响因子:
4.6
作者:
[Wilson, Claire A., Santorelli, Gillian, Howard, Louise M., Ismail, Khalida, Reynolds, Rebecca M., Simonoff, Emily]
通讯作者:
Simonoff, Emily
DOI:
10.1186/s12884-024-06250-3
发表时间:
2024-01-15
期刊:
BMC pregnancy and childbirth
影响因子:
3.1
作者:
[]
通讯作者:
DOI:
10.1056/nejmoa2303911
发表时间:
2023-10-05
期刊:
NEW ENGLAND JOURNAL OF MEDICINE
影响因子:
158.5
作者:
[Lee, Tara T. M., Collett, Corinne, Murphy, Helen R.]
通讯作者:
Murphy, Helen R.
DOI:
10.1038/s41588-023-01520-w
发表时间:
2023-11
期刊:
NATURE GENETICS
影响因子:
30.8
作者:
[Beaumont, Robin N., Flatley, Christopher, Vaudel, Marc, Wu, Xiaoping, Chen, Jing, Moen, Gunn-Helen, Skotte, Line, Helgeland, Oyvind, Sole-Navais, Pol, Banasik, Karina, Albinana, Clara, Ronkainen, Justiina, Fadista, Joao, Stinson, Sara Elizabeth, Trajanoska, Katerina, Wang, Carol A., Westergaard, David, Srinivasan, Sundararajan, Sanchez-Soriano, Carlos, Bilbao, Jose Ramon, Allard, Catherine, Groleau, Marika, Kuulasmaa, Teemu, Leirer, Daniel J., White, Frederique, Jacques, Pierre-Etienne, Cheng, Haoxiang, Hao, Ke, Andreassen, Ole A., Asvold, Bjorn Olav, Atalay, Mustafa, Bhatta, Laxmi, Bouchard, Luigi, Brumpton, Ben Michael, Brunak, Soren, Bybjerg-Grauholm, Jonas, Ebbing, Cathrine, Elliott, Paul, Engelbrechtsen, Line, Erikstrup, Christian, Estarlich, Marisa, Franks, Stephen, Gaillard, Romy, Geller, Frank, Grove, Jakob, Hougaard, David M., Kajantie, Eero, Morgen, Camilla S., Nohr, Ellen A., Nyegaard, Mette, Palmer, Colin N. A., Pedersen, Ole Birger, Rivadeneira, Fernando, Sebert, Sylvain, Shields, Beverley M., Stoltenberg, Camilla, Surakka, Ida, Thorner, Lise Wegner, Ullum, Henrik, Vaarasmaki, Marja, Vilhjalmsson, Bjarni J., Willer, Cristen J., Lakka, Timo A., Gybel-Brask, Dorte, Bustamante, Mariona, Hansen, Torben, Pearson, Ewan R., Reynolds, Rebecca M., Ostrowski, Sisse R., Pennell, Craig E., Jaddoe, Vincent W. V., Felix, Janine F., Hattersley, Andrew T., Melbye, Mads, Lawlor, Deborah A., Hveem, Kristian, Werge, Thomas, Nielsen, Henriette Svarre, Magnus, Per, Evans, David M., Jacobsson, Bo, Jarvelin, Marjo-Riitta, Zhang, Ge, Hivert, Marie-France, Johansson, Stefan, Freathy, Rachel M., Feenstra, Bjarke, Njolstad, Pal R., Beaumont, Robin N., Flatley, Christopher, Vaudel, Marc, Wu, Xiaoping, Moen, Gunn-Helen, Skotte, Line, Helgeland, Oyvind, Sole-Navais, Pol, Ronkainen, Justiina, Fadista, Joao, Stinson, Sara Elizabeth, Wang, Carol A., Bilbao, Jose Ramon, Atalay, Mustafa, Elliott, Paul, Gaillard, Romy, Geller, Frank, Morgen, Camilla S., Nohr, Ellen A., Sebert, Sylvain, Lakka, Timo A., Bustamante, Mariona, Hansen, Torben, Reynolds, Rebecca M., Pennell, Craig E., Jaddoe, Vincent W. V., Felix, Janine F., Hattersley, Andrew T., Melbye, Mads, Lawlor, Deborah A., Magnus, Per, Evans, David M., Jacobsson, Bo, Jarvelin, Marjo-Riitta, Zhang, Ge, Hivert, Marie-France, Johansson, Stefan, Freathy, Rachel M., Feenstra, Bjarke, Njolstad, Pal R.]
通讯作者:
Njolstad, Pal R.
DOI:
10.1038/s41591-023-02502-5
发表时间:
2023-10-05
期刊:
NATURE MEDICINE
影响因子:
82.9
作者:
[Tobias,Deirdre K., Merino,Jordi, Franks,Paul W.]
通讯作者:
Franks,Paul W.
Non-invasive biomarkers of stress in mothers, fathers and infants in urban and rural Malawi: a feasibility study
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批准号:MR/T038683/1
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项目类别:Research Grant
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资助金额:$12.33万
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财政年份:2021
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负责人:Rebecca Reynolds
-
依托单位:
WORKSHOP: Consortium for the Science of Sociotechnical Systems Research Summer Institute 2019
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批准号:1922868
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项目类别:Standard Grant
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资助金额:$2.0万
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财政年份:2019
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负责人:Rebecca Reynolds
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依托单位:
海外基金