Child educational progress in Born in Bradford pregnancies affected by gestational diabetes and also exposed to maternal common mental disorders.
Child educational progress in Born in Bradford pregnancies affected by gestational diabetes and also exposed to maternal common mental disorders.
复制标题
DOI：
10.1038/s41598-023-44619-0
复制
发表时间：
2023-10-21
影响因子：
4.6
通讯作者：
Simonoff, Emily
中科院分区：
文献类型：
--
作者：
Wilson, Claire A.;Santorelli, Gillian;Howard, Louise M.;Ismail, Khalida;Reynolds, Rebecca M.;Simonoff, Emily
妊娠糖尿病以及母亲焦虑和抑郁等精神障碍与后代不良神经行为结果有关，但这些暴露仅被单独研究。在英国出生的布拉德福德队列中，1051 名其母亲被诊断患有妊娠期糖尿病的儿童与孕产妇初级保健记录相关联，提供了抑郁和焦虑的诊断和治疗代码。教育记录链接提供了从五岁入学第一年开始的早期基础阶段概况结果。在广义估计方程框架内使用多变量泊松回归分析了未达到“良好发展水平”的风险。对缺失数据进行多重插补。有限的证据表明，那些额外暴露于母亲精神障碍的母亲无法达到“良好发育水平”的风险增加（调整后的 RR 1.21；95% CI 0.94，1.55）。然而，巴基斯坦裔母亲的儿童（调整后的 RR 1.36；95% CI 1.04，1.77）比英国白人的儿童有更多的证据；这可能是由于英语不是家庭中使用的主要语言所致。因此，对于某些患有 GDM 的群体来说，优化母亲的身心健康以改善儿童的结局可能尤为重要。
Gestational diabetes and the maternal mental disorders of anxiety and depression have been implicated in adverse offspring neuro-behavioural outcomes but these exposures have only been studied in isolation. 1051 children whose mothers were diagnosed with gestational diabetes in UK’s Born in Bradford cohort had linkage to maternal primary care records, providing diagnostic and treatment codes for depression and anxiety. Education record linkage provided results of the Early Years Foundation Stage Profile from the first year of school, aged five. Risk of not attaining a ‘Good level of development’ was analysed using multivariable Poisson regression within a generalised estimating equation framework. Multiple imputation was implemented for missing data. There was limited evidence of increased risk of failure to attain a ‘good level of development’ in those additionally exposed to maternal mental disorders (adjusted RR 1.21; 95% CI 0.94, 1.55). However, there was more evidence in children of Pakistani maternal ethnicity (adjusted RR 1.36; 95% CI 1.04, 1.77) than White British; this may have been driven by English not being the primary language spoken in the home. Therefore there may be groups with GDM in whom it is particularly important to optimise both maternal physical and mental health to improve child outcomes.
登录
查看更多内容
影响因子：
2.1
作者：
Ratzon, Navah;Greenbaum, Charles;Ornoy, Asher
通讯作者：
Ornoy, Asher
影响因子：
3.5
作者：
Kim, C;Brawarsky, P;Haas, JS
通讯作者：
Haas, JS
影响因子：
6.1
作者：
Olivennes, F
通讯作者：
Olivennes, F
影响因子：
2.8
作者：
Mortensen, EL;Michaelsen, KF;Reinisch, JM
通讯作者：
Reinisch, JM
DOI：
10.1192/bjp.bp.114.158832
发表时间：
2016-05
期刊：
The British journal of psychiatry : the journal of mental science
影响因子：
--
作者：
Prady SL;Pickett KE;Petherick ES;Gilbody S;Croudace T;Mason D;Sheldon TA;Wright J
通讯作者：
Wright J