DEPRESSION, PEPTIDES AND STEROIDS IN CUSHINGS SYNDROME

库欣综合征中的抑郁症、肽和类固醇

• 批准号: 6113337
• 负责人: MONICA N STARKMAN
• 金额: $ 0.02万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6113337
• 关键词: Cushing's syndrome; adrenocorticotropic hormone; clinical research; cognition; corticotropin releasing factor; cortisol; depression; dexamethasone; endorphins; hormone regulation /control mechanism; human subject; metyrapone; neuropharmacology; prognosis; psychopharmacology; secretion; sleep

We are studying cortisol, ACTH, and BLPH-'-endorphin secretory profiles in patients with untreated Cushing's Disease during baseline conditions and during CRH, metyrapone and dexamethasone challenge. We are testing the hypothesis that heterogeneity in the severity of depressive syndrome: mood, cognition, and sleep, is associated with heterogeneity in the profiles of cortisol and the pituitary peptides ACTH and BLPH-BE.

我们正在研究未治疗的库欣病患者在基线条件下和在CRH、甲吡酮和地塞米松激发期间的皮质醇、ACTH和BLPH-内啡肽分泌谱。 我们正在检验这样一个假设，即抑郁综合征的严重程度（情绪、认知和睡眠）的异质性与皮质醇和垂体肽ACTH和BLPH-BE的异质性有关。