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DEPRESSION, PEPTIDES AND STEROIDS IN CUSHINGS SYNDROME

DEPRESSION, PEPTIDES AND STEROIDS IN CUSHINGS SYNDROME
库欣综合征中的抑郁症、肽和类固醇
批准号：
6113337
负责人：
MONICA N STARKMAN
金额：
$0.02万
依托单位：
UNIVERSITY OF MICHIGAN AT ANN ARBOR
依托单位国家：
美国
项目类别：
财政年份：
1998
资助国家：
美国
项目状态：
已结题
起止时间：
1998-12-01 至 1999-11-30
来源：
https://reporter.nih.gov/project-details/6113337
关键词：
Cushing's syndrome adrenocorticotropic hormone clinical research cognition corticotropin releasing factor cortisol depression dexamethasone endorphins hormone regulation /control mechanism human subject metyrapone neuropharmacology prognosis psychopharmacology secretion sleep

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中文摘要
翻译
我们正在研究未经治疗的库欣病患者在基线条件和CRH、metyrapone和地塞米松刺激期间的皮质醇、ACTH和BLPH-内啡肽分泌谱。我们正在测试这样一个假设，即抑郁综合征严重程度的异质性：情绪、认知和睡眠，与皮质醇和垂体肽ACTH和BLPH-BE的异质性有关。
英文摘要
We are studying cortisol, ACTH, and BLPH-'-endorphin secretory profiles in patients with untreated Cushing's Disease during baseline conditions and during CRH, metyrapone and dexamethasone challenge. We are testing the hypothesis that heterogeneity in the severity of depressive syndrome: mood, cognition, and sleep, is associated with heterogeneity in the profiles of cortisol and the pituitary peptides ACTH and BLPH-BE.
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会议论文
STEROIDS, COGNITION AND IMAGING IN CUSHING'S SYNDROME
VERB MEMORY & EMOTION PERCEPTION IN FMRI FOR CUSHING'S DISEASE PATIENTS
STEROIDS, COGNITION AND IMAGING IN CUSHING'S SYNDROME
VERB MEMORY & EMOTION PERCEPTION IN FMRI FOR CUSHING'S DISEASE PATIENTS
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