STEROIDS, COGNITION AND IMAGING IN CUSHING'S SYNDROME

库欣综合征中的类固醇、认知和影像

• 批准号: 7603702
• 负责人: MONICA N STARKMAN
• 金额: $ 2.64万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-03-01 至 2007-09-16
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7603702
• 关键词: Affect; Aftercare; Alzheimer' s Disease; Animals; Brain; Brain Part; Brain region; Cognition; Computer Retrieval of Information on Scientific Projects Database; Condition; Cushing Syndrome; Elevation; Funding; Grant; Hippocampus (Brain); Hormones; Human; Hydrocortisone; Image; Impairment; Institution; Knowledge; Learning; Libido; Magnetic Resonance Imaging; Major Depressive Disorder; Memory; Moods; Neuropsychological Tests; Patients; Purpose; Research; Research Personnel; Resources; Severities; Source; Specificity; Steroids; Symptoms; Toxic effect; United States National Institutes of Health; older patient; steroid hormone; volunteer

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Elevated levels of the hormone cortisol are found in older patients with Alzheimer's Disease and in Major Depressive Disorder. Animal studies show that high levels of cortisol affect the hippocampus, the part of the brain involved in memory and learning. Patients with Cushing's Syndrome (CS) have highly elevated cortisol levels for months or years and develop symptoms such as abnormal mood, sex drive, learning and memory. The studies we propose will advance knowledge about the effect of elevated cortisol on the brain in humans. Animal studies also show that a toxic effect of cortisol on the hippocampus is the likely mechanism by which elevated steroids produce these symptoms. We will use magnetic resonance imaging (MRI) of the brain together with specific neuropsychological tests (NPT) to investigate such a mechanism on patients with CS. We will examine, prior to treatment, the volume of the hippocampus (HFV) in CS patients, and compare it to matched healthy research volunteers. We will then examine the association between the severity of cortisol elevation, NPT impairment and HFV. Other brain regions will be used as comparisons to examine the specificity of the association. Since cortisol levels normalize after treatment, we will study if these changes are reversible. For this purpose, we will repeat NPT and MRI 12 and 24 months following treatment. In addition to CS, these studies will help understand the impact of steroid hormones on the brain of patients with a wide variety of illnesses requiring long-term steroid treatment and other conditions in which steroid hormones are secreted abnormally.'

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 在老年痴呆症和严重抑郁症患者中发现皮质醇激素水平升高。 动物研究表明，高水平的皮质醇会影响海马体，这是大脑中与记忆和学习有关的部分。 患有库欣综合征（CS）的患者具有数月或数年的高度升高的皮质醇水平，并且发展出诸如异常情绪、性欲、学习和记忆的症状。 我们提出的研究将推进关于皮质醇升高对人类大脑影响的知识。动物研究还表明，皮质醇对海马体的毒性作用可能是类固醇升高产生这些症状的机制。 我们将使用磁共振成像（MRI）的大脑与特定的神经心理学测试（NPT），以调查这样的机制与CS患者。 我们将在治疗前检查CS患者的海马体积（HFV），并将其与匹配的健康研究志愿者进行比较。 然后我们将研究皮质醇升高的严重程度、NPT受损和HFV之间的关联。 其他大脑区域将被用作比较，以检查这种关联的特异性。 由于治疗后皮质醇水平恢复正常，我们将研究这些变化是否可逆。 为此，我们将在治疗后12个月和24个月重复NPT和MRI。 除了CS，这些研究将有助于了解类固醇激素对患有各种需要长期类固醇治疗的疾病和类固醇激素分泌异常的其他疾病的患者大脑的影响。'