PET EVALUATION OF NEUROENDOCRINE TUMORS AND OTHER TUMORS OF CHILDHOOD

神经内分泌肿瘤和其他儿童肿瘤的 PET 评估

• 批准号: 6297132
• 负责人: BARRY L SHULKIN
• 金额: $ 0.02万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6297132
• 关键词: bioimaging /biomedical imaging; child (0-11); clinical research; diagnosis design /evaluation; endocrine neoplasm; human subject; neoplasm /cancer diagnosis; neuroendocrine system; noninvasive diagnosis; pediatric neoplasm /cancer; positron emission tomography; radiotracer

Positron emission tomography (PET) is a non-invasive medical imaging technique which utilizes specialized tracers to depict both physiologic and pathophysiologic processes. The aim of this proposal is to apply PET technology for the detection, characterization, and assessment of the response to therapy of tumors derived from the sympathetic nervous system in adults, and these tumors and other solid malignancies in children. We expect to show, by virtue of the superior image resolution of PET technology, an advance in ability to detect these tumors. In patients undergoing radiation or chemotherapy, it is anticipated that serial studies will show that changes in tumor uptake reflect the tissue response to treatment and serve as an early indicator of therapeutic efficacy or failure. If such information can be made available noninvasively by PET scanning, the management of patients with these tumors could be substantially improved.

正电子发射断层扫描（PET）是一种非侵入性医学成像技术，它利用专门的示踪剂来描绘生理和病理生理过程。 该提案的目的是应用PET技术检测、表征和评估成人交感神经系统肿瘤以及儿童这些肿瘤和其他实体恶性肿瘤的治疗反应。 我们期望通过PET技术的上级图像分辨率，显示出检测这些肿瘤的能力的进步。 在接受放疗或化疗的患者中，预计系列研究将显示肿瘤摄取的变化反映了组织对治疗的反应，并可作为治疗有效性或失败的早期指标。如果这些信息可以通过PET扫描非侵入性地获得，则这些肿瘤患者的管理可以得到实质性改善。