PET EVALUATION OF NEUROENDOCRINE TUMORS AND OTHER TUMORS OF CHILDHOOD

正电子发射断层扫描（PET）是一种非侵入性医学成像技术，它利用专门的示踪剂来描述生理和病理生理过程。本提案的目的是将PET技术应用于检测、表征和评估成人交感神经系统肿瘤的治疗反应，以及这些肿瘤和儿童的其他实体恶性肿瘤。我们期望通过PET技术优越的图像分辨率表明，预计一系列研究将表明肿瘤摄取的变化反映了组织对治疗的反应，并作为治疗效果或失败的早期指标。如果这些信息可以通过PET扫描无创地获得，肿瘤患者的管理可以大大改善。

Positron emission tomography (PET) is a non-invasive medical imaging technique which utilizes specialized tracers to depict both physioligic and pathophysiologic processes. The aim of this proposal is to apply PET technology for the detection, characterization, and assessment of the response to therapy of tumors derived from the sympathetic nervous system in adults, and these tumors and other solid malignancies in children. We expect to show, by virtue of the superior image resolution of PET technology, it is anticipated that serial studies will show that changes in tumor uptake reflect the tissue response to treatment and serve as an early indicator of therapeutic efficacy or failure. If such information can be made available noninvasively by PET scanning, the management of patients with tumors could be substantially improved.