PET EVALUATION OF NEUROENDOCRINE TUMORS AND OTHER TUMORS OF CHILDHOOD

神经内分泌肿瘤和其他儿童肿瘤的 PET 评估

• 批准号: 6113356
• 负责人: BARRY L SHULKIN
• 金额: $ 0.02万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6113356
• 关键词: bioimaging /biomedical imaging; child (0-11); clinical research; diagnosis design /evaluation; endocrine neoplasm; human subject; neoplasm /cancer diagnosis; neuroendocrine system; noninvasive diagnosis; pediatric neoplasm /cancer; positron emission tomography; radiotracer

Positron emission tomography (PET) is a non-invasive medical imaging technique which utilizes specialized tracers to depict both physioligic and pathophysiologic processes. The aim of this proposal is to apply PET technology for the detection, characterization, and assessment of the response to therapy of tumors derived from the sympathetic nervous system in adults, and these tumors and other solid malignancies in children. We expect to show, by virtue of the superior image resolution of PET technology, it is anticipated that serial studies will show that changes in tumor uptake reflect the tissue response to treatment and serve as an early indicator of therapeutic efficacy or failure. If such information can be made available noninvasively by PET scanning, the management of patients with tumors could be substantially improved.

正电子发射断层扫描 (PET) 是一种非侵入性医学成像技术，利用专门的示踪剂来描绘生理和病理生理过程。 该提案的目的是应用 PET 技术来检测、表征和评估成人交感神经系统肿瘤以及儿童这些肿瘤和其他实体恶性肿瘤的治疗反应。 我们希望凭借 PET 技术卓越的图像分辨率，系列研究将表明肿瘤摄取的变化反映了组织对治疗的反应，并作为治疗效果或失败的早期指标。 如果可以通过 PET 扫描无创地提供此类信息，则可以大大改善肿瘤患者的治疗。