PET EVALUATION OF NEUROENDOCRINE TUMORS AND OTHER TUMORS OF CHILDHOOD

正电子发射断层扫描（PET）是一种非侵入性的医学成像技术，它利用专门的示踪剂来描绘生理和病理生理过程。 该提案的目的是应用PET技术检测、表征和评估成人交感神经系统肿瘤以及儿童这些肿瘤和其他实体恶性肿瘤的治疗反应。 我们希望通过PET技术的上级图像分辨率显示，预期系列研究将显示肿瘤摄取的变化反映了组织对治疗的反应，并作为治疗有效性或失败的早期指标。 如果这些信息可以通过PET扫描非侵入性地获得，则肿瘤患者的管理可以得到实质性的改善。

Positron emission tomography (PET) is a non-invasive medical imaging technique which utilizes specialized tracers to depict both physioligic and pathophysiologic processes. The aim of this proposal is to apply PET technology for the detection, characterization, and assessment of the response to therapy of tumors derived from the sympathetic nervous system in adults, and these tumors and other solid malignancies in children. We expect to show, by virtue of the superior image resolution of PET technology, it is anticipated that serial studies will show that changes in tumor uptake reflect the tissue response to treatment and serve as an early indicator of therapeutic efficacy or failure. If such information can be made available noninvasively by PET scanning, the management of patients with tumors could be substantially improved.