TROVAFLOXACIN: AN ALTERNATIVE FLUOROQUINOLONE IN PATIENTS STABILIZED

本研究探讨了环丙沙星、左氧氟沙星和曲瓦沙星中性离子与肾近端小管阳离子普鲁卡因酰胺之间的潜在相互作用。将招募8名青年（18-40岁）和8名老年（65岁以上）受试者。计算普鲁卡因酰胺和n-乙酰普鲁卡因酰胺（NAPA）单独和与每种氟喹诺酮类药物联合使用的药代动力学参数。普鲁卡因胺的平均药代动力学参数将与联合参数进行比较。将比较老年人和年轻人的平均药代动力学值。这一点很重要，因为普鲁卡因酰胺（和NAPA）的治疗指数较窄，而且血清普鲁卡因酰胺水平升高会增加毒性风险。

The study examines the potential interactions between the zwitterions ciprofloxacin, levofloxacin and trovafloxacin and the cation procainamide in proximal renal tubule. Eight young (18-40 years) and 8 elderly (+65 years) subjects will be enrolled. Pharmacokinetic parameters for procainamide and n-acetylprocainamide (NAPA) alone and in combination with each fluoroquinolone will be calculated. Mean pharmacokinetic parameters for procainamide will be compared to combination parameters. Comparisons of mean pharmacokinetic values for the elderly and young groups will be made. This is significant because of the narrow therapeutic index of procainamide (and NAPA) and the increased risk of toxicity associated with elevated serum levels of procainamide.