TROVAFLOXACIN: AN ALTERNATIVE FLUOROQUINOLONE IN PATIENTS STABILIZED

本研究考察了两性离子环丙沙星、左氧氟沙星和曲伐他汀与阳离子普鲁卡因胺在近端肾小管中的潜在相互作用。 将入组8例年轻（18-40岁）和8例老年（65岁以上）受试者。 将计算普鲁卡因胺和n-乙酰普鲁卡因胺（NAPA）单独给药以及与每种氟喹诺酮联合给药的药代动力学参数。 将普鲁卡因胺的平均药代动力学参数与联合用药参数进行比较。 将比较老年组和年轻组的平均药代动力学值。这是重要的，因为普鲁卡因胺（和NAPA）的治疗指数较窄，并且与普鲁卡因胺血清水平升高相关的毒性风险增加。

The study examines the potential interactions between the zwitterions ciprofloxacin, levofloxacin and trovafloxacin and the cation procainamide in proximal renal tubule. Eight young (18-40 years) and 8 elderly (+65 years) subjects will be enrolled. Pharmacokinetic parameters for procainamide and n-acetylprocainamide (NAPA) alone and in combination with each fluoroquinolone will be calculated. Mean pharmacokinetic parameters for procainamide will be compared to combination parameters. Comparisons of mean pharmacokinetic values for the elderly and young groups will be made. This is significant because of the narrow therapeutic index of procainamide (and NAPA) and the increased risk of toxicity associated with elevated serum levels of procainamide.